In the intricate world of pharmaceutical development, the precise selection and sourcing of chemical intermediates are crucial for the successful synthesis of novel drug compounds. 1-Boc-piperidine-4-carboxaldehyde, identified by its CAS number 137076-22-3, has emerged as a particularly valuable building block for medicinal chemists and process development teams. As a trusted supplier of fine chemicals, we understand the importance of this compound and aim to illuminate its significance for B2B clients involved in drug discovery and manufacturing.

1-Boc-piperidine-4-carboxaldehyde: A Versatile Chemical Intermediate

Characterized by its white crystal powder appearance and high purity (typically 97% minimum), 1-Boc-piperidine-4-carboxaldehyde (C11H19NO3) offers a unique combination of a protected amine and a reactive aldehyde. This bifunctional nature allows it to participate in a wide range of chemical transformations, making it an indispensable component in the synthesis of complex organic molecules. The tert-butoxycarbonyl (Boc) protecting group ensures selective reactivity of the piperidine nitrogen, while the formyl group is readily amenable to nucleophilic additions, reductive aminations, and other aldehyde-specific reactions.

Key Applications in Pharmaceutical Synthesis

The utility of 1-Boc-piperidine-4-carboxaldehyde is most prominently seen in its role as a precursor for various classes of pharmaceutical agents. Its applications include:

  • Inhibitor Synthesis: It is a key reactant in the synthesis of Pim-1 inhibitors, which are investigated for their role in cancer therapy. It is also used in the creation of HDAC inhibitors, a promising class of drugs for oncology and other diseases.
  • Agonist Development: The compound is employed in synthesizing selective GPR119 agonists, a therapeutic target for managing type II diabetes.
  • Antiviral Research: It serves as a reactant in the development of M-tropic (R5) HIV-1 replication inhibitors, contributing to the ongoing fight against HIV.
  • Neuroscience: In the field of neuroscience, it's used in the synthesis of selective 5-HT6 antagonists, which are being explored for cognitive disorders like Alzheimer's disease.
  • Methodology Development: The compound is also valuable in developing new synthetic methodologies, such as three-component vinylogous Mannich reactions, pushing the boundaries of organic chemistry.

Why Choose a Reliable Manufacturer?

For pharmaceutical companies and contract research organizations (CROs), obtaining a consistent supply of high-quality 1-Boc-piperidine-4-carboxaldehyde is critical. Partnering with a reputable manufacturer or supplier, especially one with a strong presence in China, ensures:

  • Guaranteed Purity: Reliable suppliers provide Certificates of Analysis (CoA) confirming the 97% minimum purity, essential for meeting stringent pharmaceutical quality standards.
  • Competitive Pricing: Access to competitive market pricing for CAS 137076-22-3 can significantly reduce overall project costs. Bulk purchase agreements are often available.
  • Scalability: A good supplier can support your needs from research quantities to pilot-scale and commercial manufacturing, ensuring a seamless transition as your project progresses.
  • Technical Support: Expert advice on handling, storage, and specific reaction conditions can be invaluable.

Conclusion: Your Partner in Pharmaceutical Synthesis

1-Boc-piperidine-4-carboxaldehyde is more than just a chemical; it's an enabler of therapeutic innovation. By selecting a reliable supplier for this vital intermediate, B2B customers can optimize their research, development, and manufacturing processes. We are committed to providing high-quality chemical building blocks like 1-Boc-piperidine-4-carboxaldehyde to the global pharmaceutical industry, ensuring reliability and competitive pricing. Contact us to learn more about how we can support your next project.