In the intricate world of chemical synthesis, the selection of the right building blocks dictates the success of developing novel compounds. 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene, identified by CAS number 146447-18-9, stands out as a particularly valuable organic intermediate. Its unique molecular architecture makes it a sought-after compound for researchers and manufacturers across pharmaceuticals, agrochemicals, and material sciences. This article delves into its properties and applications, emphasizing how to effectively acquire this essential chemical.

Chemical Properties and Reactivity

1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene is characterized by a benzene ring substituted with a bromine atom, a chlorine atom, a fluorine atom, and a methoxy group. This arrangement offers:

  • Halogen Reactivity: The presence of multiple halogens provides diverse sites for various organic reactions, including nucleophilic aromatic substitution, cross-coupling reactions (like Suzuki, Heck, or Sonogashira couplings), and lithiation. These reactions are foundational for constructing complex molecular scaffolds.
  • Methoxy Group Influence: The electron-donating methoxy group can influence the electronic properties of the benzene ring, potentially directing regioselectivity in further reactions and affecting solubility in common organic solvents like methanol.
  • Physical Characteristics: Typically supplied as a white to light yellow solid, with a melting point range of 72.0 to 76.0 °C, it is stable under room temperature conditions when stored properly.

Applications Driving Demand

The demand for 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene is driven by its pivotal role in synthesis:

  • Pharmaceutical R&D: As a key intermediate, it is instrumental in the synthesis of various drug candidates and APIs. For instance, its halogen substitutions can be crucial for modulating pharmacokinetic properties such as absorption, distribution, metabolism, and excretion (ADME), as well as for improving drug potency. If you need to buy pharmaceutical intermediates, this is a prime example.
  • Agrochemical Innovation: In the agrochemical industry, this compound contributes to the creation of new pesticides and crop protection agents. Its structural features can lead to more effective and environmentally conscious formulations. Consider it when looking for agrochemical intermediates for sale.
  • Advanced Materials: Its incorporation into novel materials can lead to enhanced electronic or optical properties, making it relevant for applications in organic electronics, OLEDs, and specialized coatings.

Procuring Your Chemical Needs

For businesses seeking to purchase chemical raw materials like 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene, identifying a reliable chemical supplier is key. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a premier manufacturer and provider of high-quality chemical intermediates. We offer competitive chemical pricing and ensure the consistent availability of products like this essential building block. Our expertise in custom synthesis also means we can cater to specific project requirements.

Engaging with a trusted chemical manufacturer in China provides access to both quality products and cost-effective solutions. We encourage you to contact us for quotes and to discuss your specific needs, ensuring you receive the best materials for your groundbreaking research and production.