In the realm of advanced organic synthesis, the utility of specific chemical intermediates cannot be overstated. 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene, bearing CAS number 146447-18-9, is a prime example of such a versatile compound. Its intricate structure, featuring a precisely substituted benzene ring, makes it a valuable asset for chemists involved in pharmaceuticals, agrochemicals, and cutting-edge material development. This article highlights its significance and provides insights for procurement.

Structural Advantages for Synthesis

The molecular architecture of 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene is key to its broad applicability:

  • Multi-Halogenation: The presence of three different halogens—bromine, chlorine, and fluorine—on the aromatic ring provides multiple reactive sites. These halogens can be selectively manipulated through various established organic reactions, such as metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), nucleophilic aromatic substitutions, and Grignard reagent formation. This allows chemists to precisely introduce complex functional groups and build intricate molecular frameworks.
  • Methoxy Group: The methoxy ether group (-OCH3) influences the electronic distribution of the benzene ring, which can affect reaction regioselectivity and enhance solubility in polar organic solvents, facilitating smoother synthetic processes.
  • Physical Properties: Typically appearing as a white to light yellow solid with a defined melting point (72-76 °C), it offers good handling characteristics for laboratory and industrial use, assuming proper storage conditions.

Applications Across Key Industries

The utility of 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene spans several high-value sectors:

  • Pharmaceuticals: It is an indispensable intermediate for synthesizing novel drug candidates and Active Pharmaceutical Ingredients (APIs). The strategically placed halogens can significantly impact a drug's bioavailability, metabolic stability, and receptor binding affinity, contributing to enhanced therapeutic outcomes. If you are looking to buy pharmaceutical intermediates, this compound offers significant advantages.
  • Agrochemicals: In the development of crop protection agents like herbicides and fungicides, this intermediate plays a vital role in crafting molecules with improved efficacy and selectivity, promoting sustainable agriculture. For those seeking agrochemical intermediates for sale, its utility is well-established.
  • Materials Science: Its unique electronic and structural properties make it suitable for creating advanced materials with specific optical or conductive characteristics, finding use in organic electronics, sensors, and specialized coatings.

Procurement Best Practices

For businesses and researchers in the B2B sector, sourcing essential chemicals like 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene requires careful consideration of suppliers. NINGBO INNO PHARMCHEM CO.,LTD. stands as a dedicated chemical manufacturer and supplier committed to providing high-purity intermediates. We emphasize rigorous quality control, competitive chemical pricing, and reliable delivery. We encourage you to reach out to us for quotes and to discuss your specific synthesis needs, ensuring you obtain this critical component from a trusted chemical manufacturer in China.