The field of pharmaceutical synthesis relies heavily on precisely engineered chemical intermediates to build complex drug molecules. Among these, 1-Formylpiperidine-4-carboxylic Acid (CAS: 84163-42-8) stands out due to its specific structural features and critical role in the production of important APIs. As a chemical building block, its utility is primarily recognized in its application as a precursor for Risperidone, a widely prescribed antipsychotic medication. Understanding its chemical properties and how to procure it efficiently is key for any pharmaceutical R&D scientist or procurement manager.

Chemical Profile of 1-Formylpiperidine-4-carboxylic Acid

This compound, appearing as a white powder, possesses the molecular formula C7H11NO3 and a molecular weight of approximately 157.17 g/mol. Its chemical structure features a piperidine ring substituted with a formyl group on the nitrogen atom and a carboxylic acid group at the 4-position. This dual functionality makes it an attractive starting material for various organic reactions, including condensations, reductions, and esterifications. The melting point of 137-138°C indicates its solid state under standard conditions.

Key Application: Intermediate for Risperidone Synthesis

The most prominent application of 1-Formylpiperidine-4-carboxylic Acid is its use as a direct intermediate in the synthesis of Risperidone (CAS: 106266-06-2). Risperidone is a second-generation antipsychotic used to treat schizophrenia, bipolar disorder, and irritability associated with autism. The structural integrity and purity of 1-Formylpiperidine-4-carboxylic Acid directly impact the yield and quality of the final Risperidone API. Pharmaceutical manufacturers looking to buy 1-Formylpiperidine-4-carboxylic Acid for this purpose seek suppliers who can guarantee consistent quality and availability.

Beyond Risperidone: Potential Research Applications

While its role in Risperidone synthesis is well-established, the versatile nature of 1-Formylpiperidine-4-carboxylic Acid also lends itself to broader applications in pharmaceutical research and development:

  • Building Block for Novel APIs: Its piperidine scaffold and reactive functional groups make it an excellent starting point for the synthesis of other novel pharmaceutical compounds with potential therapeutic activities. Researchers can leverage its structure to create diverse chemical libraries for drug discovery screening.
  • Medicinal Chemistry Studies: The compound can be used in structure-activity relationship (SAR) studies, where modifications to its formyl or carboxylic acid groups can help elucidate the biological activity of related molecules.
  • Custom Synthesis Projects: For specialized drug development projects, 1-Formylpiperidine-4-carboxylic Acid can be incorporated into custom synthesis pathways to create bespoke intermediates or target molecules.

Procurement Guidance

When sourcing 1-Formylpiperidine-4-carboxylic Acid, consider its purity (typically >98.0%) and the reliability of the manufacturer or supplier. As a crucial intermediate, securing a stable supply chain is vital. If you are looking to purchase 1-Formylpiperidine-4-carboxylic Acid, our company, a leading Chinese supplier, offers this product with assured quality and competitive pricing. Contact us for a quotation or to discuss your specific requirements for this essential pharmaceutical intermediate.