In the dynamic field of chemical synthesis, certain molecules stand out for their versatility and utility. 1-Methyl-3-phenyl-1H-pyrazol-5-amine, identified by CAS number 10199-50-5, is one such compound. As a vital pharmaceutical intermediate, it plays a crucial role in the creation of a wide range of complex organic compounds. Understanding its properties and applications is key for researchers and procurement managers seeking high-quality chemical building blocks.

Understanding the Chemistry

1-Methyl-3-phenyl-1H-pyrazol-5-amine possesses a molecular formula of C10H11N3 and a molecular weight of 173.21 g/mol. Its structure features a pyrazole ring, substituted with a methyl group and a phenyl group, along with a reactive amine functional group. Typically supplied as a white to yellow solid, its melting point falls within the range of 125-128°C. The high purity (often 99% or greater) ensures its suitability for demanding synthetic processes, minimizing unwanted side reactions and maximizing yields.

Applications in Organic Synthesis

The significance of 1-Methyl-3-phenyl-1H-pyrazol-5-amine lies in its role as a fundamental building block. Its amine group readily participates in various reactions, including amide formation, Schiff base condensation, and nucleophilic substitutions. The pyrazole core itself is a prevalent motif in many biologically active molecules, making this compound invaluable for:

  • Pharmaceutical Drug Discovery: It serves as a precursor for synthesizing novel drug candidates targeting various diseases. Its structural features can be modified to enhance efficacy, selectivity, and pharmacokinetic properties.
  • Agrochemical Development: Similar to pharmaceuticals, pyrazole derivatives are found in many pesticides and herbicides, and this intermediate can be used in their synthesis.
  • Materials Science: Its unique electronic and structural properties can also be leveraged in the development of advanced materials, such as organic semiconductors or specialized polymers.

Procurement Strategies for Researchers

For research scientists and product formulators, sourcing this intermediate efficiently is important. When you need to buy 1-Methyl-3-phenyl-1H-pyrazol-5-amine, consider partnering with established chemical suppliers or manufacturers. Many companies, particularly those based in China, specialize in producing high-purity intermediates like this. Key aspects to look for include:

  • Supplier Reputation: Look for manufacturers with a strong commitment to quality control and consistent product output.
  • Purity Assurance: Always request a Certificate of Analysis (CoA) to confirm the 99% minimum purity.
  • Competitive Pricing: Obtain quotes from several suppliers to ensure you are getting the best value for your investment.
  • Sample Availability: Many suppliers offer free samples, which is an excellent way to test the material's suitability for your specific applications.

The availability of this compound from reliable manufacturers allows research teams to focus on innovation rather than struggling with supply chain issues. By choosing the right partner, you can ensure a steady supply of this critical building block for your synthetic projects.

In summary, 1-Methyl-3-phenyl-1H-pyrazol-5-amine (CAS 10199-50-5) is an indispensable tool for chemists. Its well-defined properties and versatile reactivity make it a cornerstone for developing new pharmaceuticals and fine chemicals. When you are ready to purchase, remember to prioritize purity and supplier reliability.