In the realm of pharmaceutical manufacturing, the quality and availability of specific chemical intermediates directly impact the efficacy and accessibility of essential medications. 1-Methylindazole-3-carboxylic acid (CAS: 50890-83-0) stands out as a crucial building block, primarily recognized for its role in the synthesis of Granisetron hydrochloride, a key therapeutic agent for managing nausea and vomiting.

The Chemical Identity and Importance of 1-Methylindazole-3-carboxylic Acid

With its molecular formula C9H8N2O2, 1-Methylindazole-3-carboxylic acid is a white to off-white crystalline powder. Its chemical structure and properties make it an ideal precursor for complex pharmaceutical syntheses. R&D scientists often rely on its purity (typically ≥99.0%) and well-defined physical characteristics, such as its melting point of 213-218°C, to ensure predictable reaction outcomes. The compound's solubility in common organic solvents like methanol further facilitates its use in various synthetic processes.

Granisetron Hydrochloride: A Life-Improving Application

The primary significance of 1-Methylindazole-3-carboxylic acid lies in its indispensable role in the production of Granisetron hydrochloride. Granisetron is a selective 5-HT3 receptor antagonist that effectively prevents and treats nausea and vomiting, particularly those induced by chemotherapy and radiotherapy. The reliable supply of high-purity 1-Methylindazole-3-carboxylic acid is therefore fundamental for pharmaceutical companies manufacturing this vital medication, ensuring that patients have access to effective treatments for debilitating side effects of cancer therapies.

Navigating the Purchase Process: What Buyers Need to Know

For procurement professionals looking to buy 1-Methylindazole-3-carboxylic acid, several factors are crucial. When sourcing from manufacturers, especially in competitive markets like China, it's essential to verify:

  • Purity Levels: Confirm that the product meets the required pharmaceutical grade purity (≥99.0%).
  • Supplier Reputation: Assess the manufacturer's experience and reliability in supplying pharmaceutical intermediates.
  • Documentation: Ensure availability of Certificates of Analysis (CoA) and Safety Data Sheets (SDS).
  • Pricing and Terms: Obtain competitive quotes and understand lead times, packaging (e.g., 25kg drums), and payment conditions.

Engaging directly with manufacturers can often yield better pricing and a more transparent supply chain, facilitating smoother procurement processes.

The Role in Pharmaceutical R&D

Beyond its direct application in Granisetron synthesis, 1-Methylindazole-3-carboxylic acid is also a valuable compound for pharmaceutical research and development. It can be used as a reference standard for analytical purposes, such as impurity profiling, or in studies exploring new synthetic pathways for related indole-based compounds. The consistent availability from reliable suppliers supports ongoing innovation in drug discovery.

In conclusion, 1-Methylindazole-3-carboxylic acid is a critical pharmaceutical intermediate whose importance is amplified by its role in producing Granisetron hydrochloride. By understanding its properties and prioritizing quality and reliable sourcing from manufacturers, the pharmaceutical industry can continue to meet the demand for this essential anti-nausea medication.