For professionals in the pharmaceutical and fine chemical industries, understanding the precise properties and applications of key intermediates is fundamental to successful R&D and manufacturing. 1-Methylindazole-3-carboxylic acid (CAS: 50890-83-0) is a critical compound that serves as an essential building block, most notably in the synthesis of Granisetron hydrochloride, an important antiemetic drug.

Key Chemical Properties and Specifications

1-Methylindazole-3-carboxylic acid is chemically identified by its molecular formula C9H8N2O2 and a molecular weight of 176.17. It typically presents as a white to off-white crystalline powder, a testament to its high purity, often exceeding 99.0%. This purity is a critical factor for R&D scientists, as it minimizes side reactions and ensures the integrity of the final product. Key physical properties that buyers should verify include its melting point, generally falling within the range of 213-218°C, and its solubility characteristics, often noted as soluble in methanol. The availability of detailed analytical data, such as IR spectra and impurity profiles, is crucial for quality assurance.

Primary Application: Granisetron Synthesis

The most significant application for 1-Methylindazole-3-carboxylic acid is its role as a precursor in the synthesis of Granisetron hydrochloride. Granisetron is a potent serotonin 5-HT3 receptor antagonist widely used to prevent nausea and vomiting associated with cancer treatments like chemotherapy and radiotherapy. The efficient synthesis of this API relies on the consistent availability of high-quality 1-Methylindazole-3-carboxylic acid. Procurement managers and R&D teams must ensure a stable supply chain to meet the ongoing demand for this vital medication.

Guide to Purchasing 1-Methylindazole-3-carboxylic Acid

When looking to buy 1-Methylindazole-3-carboxylic acid, professionals should consider the following:

  • Purity Standards: Prioritize suppliers offering ≥99.0% purity.
  • Supplier Reliability: Choose manufacturers with a proven track record in producing pharmaceutical intermediates. Direct sourcing from manufacturers, particularly those in China, can offer cost benefits and supply chain transparency.
  • Technical Documentation: Always request and review the Certificate of Analysis (CoA) and Safety Data Sheet (SDS).
  • Pricing and Packaging: Obtain multiple quotes to compare prices, understand bulk order discounts, and confirm packaging specifications (e.g., 25kg drums).
  • Lead Times: Inquire about delivery timelines to align with production schedules.

For R&D scientists, working closely with procurement to identify suitable suppliers who can consistently deliver within specification is essential. This collaboration ensures that the chosen intermediate meets all necessary analytical and quality requirements for successful drug development and manufacturing.

In conclusion, 1-Methylindazole-3-carboxylic acid is a cornerstone intermediate in the pharmaceutical industry, primarily due to its role in Granisetron synthesis. By understanding its properties and implementing a strategic purchasing approach, companies can secure a reliable and high-quality supply, ultimately contributing to patient care.