In the realm of pharmaceutical manufacturing, precision and purity are paramount. 1-Methylindole, a chemical entity designated by CAS number 603-76-9, represents a critical intermediate compound extensively utilized in the synthesis of advanced APIs, most notably Osimertinib. For R&D scientists and procurement specialists aiming to secure high-quality raw materials, a thorough understanding of 1-Methylindole's properties and its role in the supply chain is essential.

Chemical Profile and Specifications of 1-Methylindole

1-Methylindole is recognized for its physical characteristics, appearing as a transparent brown liquid. Its molecular formula is C9H9N, with a molecular weight of 131.174. The key specification that underscores its utility in pharmaceutical synthesis is its high assay of ≥98.0%. This purity level is crucial for ensuring the efficiency and reliability of downstream chemical reactions, particularly when producing complex APIs like Osimertinib. The chemical is typically supplied in 200 kg drums, and proper storage in a cool, ventilated environment is recommended to preserve its quality and shelf-life.

The Indispensable Role in Osimertinib Synthesis

The demand for 1-Methylindole is significantly driven by its crucial role in the manufacturing pathway of Osimertinib. Osimertinib is a targeted therapy that has revolutionized the treatment of certain lung cancers by targeting specific EGFR mutations. As a direct precursor or intermediate, 1-Methylindole contributes essential structural components to the final Osimertinib molecule. Therefore, ensuring a consistent and reliable supply of this intermediate is fundamental for pharmaceutical companies involved in the production of this important oncology drug. Its utility extends to other research and development projects that require indole-based chemical structures.

Procurement Strategy: How to Buy 1-Methylindole Effectively

When it's time to buy 1-Methylindole, a strategic procurement approach is key. This typically involves:

  • Supplier Vetting: Identifying and qualifying reliable manufacturers and suppliers is the first step. Companies looking for this intermediate often turn to established players in the global chemical market, including those in China, for competitive pricing and production capacity.
  • Quality Verification: Always insist on a detailed Certificate of Analysis (CoA) that confirms the purity (≥98.0%), CAS number (603-76-9), and other essential specifications. Understanding the supplier's quality management systems can also provide confidence.
  • Price Quotation and Negotiation: Obtaining multiple price quotes allows for informed decision-making. It's important to balance cost with quality and reliability, ensuring the purchased material meets all necessary standards for pharmaceutical applications.
  • Logistics and Packaging: Confirm that the supplier’s packaging and logistics capabilities align with your operational needs and timelines.

Conclusion

1-Methylindole (CAS 603-76-9) is a cornerstone intermediate for pharmaceutical manufacturers focused on APIs like Osimertinib. By prioritizing quality, engaging with dependable suppliers, and understanding the market dynamics, businesses can effectively source this vital chemical, ensuring the continuity and success of their pharmaceutical production processes.