In the complex world of pharmaceutical manufacturing, the quality of raw materials dictates the success of the final product. 1-Methylindole, identified by CAS number 603-76-9, is a prime example of a high-value intermediate chemical that plays a pivotal role in the synthesis of advanced pharmaceutical compounds, most notably Osimertinib. Understanding its chemical properties and application significance is crucial for procurement specialists and R&D scientists.

Understanding 1-Methylindole's Chemical Profile

1-Methylindole presents as a transparent brown liquid, possessing a molecular formula of C9H9N and a molecular weight of 131.174. Its physical and chemical properties, such as a boiling point of 239.4 °C at 760 mmHg and a flash point of 98.6 °C, are important considerations for handling and processing. The specification of an assay of ≥98.0% highlights its suitability for demanding pharmaceutical applications where impurity control is critical.

Applications in API Synthesis

The primary application driving demand for 1-Methylindole is its use as an intermediate in the synthesis of Osimertinib. Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used to treat non-small cell lung cancer (NSCLC). The precise chemical structure and purity of 1-Methylindole directly contribute to the efficient and successful synthesis of this life-saving medication. As a result, identifying reliable manufacturers who can supply this intermediate consistently is a key objective for pharmaceutical companies.

Procurement Strategy: Buying 1-Methylindole

When looking to purchase 1-Methylindole, a strategic approach to procurement is vital. This involves:

  • Supplier Identification: Searching for established manufacturers and suppliers, particularly those based in regions with strong chemical manufacturing capabilities like China, is a common starting point. This allows for competitive pricing and access to large-scale production capacities.
  • Quality Assurance: Always request and review the product's Certificate of Analysis (CoA), ensuring it meets the required specifications, especially the ≥98.0% assay. Understanding the packaging (e.g., 200 kg/drum) and recommended storage conditions is also important for maintaining product integrity.
  • Price Negotiation: Engage with suppliers to obtain quotes and negotiate pricing that aligns with your budget and project needs. However, prioritize quality and reliability over solely cost-driven decisions.
  • Technical Support: Partnering with a supplier that can offer technical support or documentation can be highly beneficial for R&D and production teams.

Conclusion

1-Methylindole (CAS 603-76-9) is more than just a chemical; it is a critical component in the pharmaceutical value chain, enabling the production of advanced therapies. By understanding its properties and strategically sourcing it from reliable manufacturers and suppliers, particularly from China, pharmaceutical companies can ensure the quality and continuity of their API production, ultimately contributing to improved patient outcomes.