In the fast-paced pharmaceutical industry, access to high-quality raw materials is critical for timely and successful drug development and manufacturing. 1-Methylindole, a chemical compound identified by CAS number 603-76-9, is a key intermediate that plays a vital role in the synthesis of important Active Pharmaceutical Ingredients (APIs), most notably Osimertinib. Understanding its characteristics and how to source it effectively is essential for R&D scientists and procurement managers.

Key Properties of 1-Methylindole

1-Methylindole is characterized by its transparent brown liquid appearance. With a molecular formula of C9H9N and a molecular weight of 131.174, it possesses specific physical and chemical properties that make it suitable for its intended applications. Its high assay of ≥98.0% ensures a level of purity necessary for demanding chemical reactions in pharmaceutical synthesis. The standard packaging of 200 kg/drum facilitates large-scale industrial use, and proper storage in a cool, ventilated place is recommended to maintain its quality.

Application in Osimertinib Synthesis and Beyond

The primary driver for the demand of 1-Methylindole is its critical function as an intermediate in the production of Osimertinib. Osimertinib is a groundbreaking targeted therapy used in the treatment of certain types of non-small cell lung cancer (NSCLC), particularly those with specific EGFR mutations. The reliable supply of pure 1-Methylindole is thus directly linked to the availability of this important cancer medication. Beyond its role in Osimertinib, 1-Methylindole, like other indole derivatives, can be a versatile building block in the synthesis of various other pharmaceutical compounds and fine chemicals, making it a valuable asset for research and development departments.

How to Buy 1-Methylindole: A Procurement Perspective

For professionals looking to buy 1-Methylindole, a structured approach to procurement is recommended:

  • Identify Reputable Suppliers: Seek out manufacturers and suppliers with a proven track record in the specialty chemical and pharmaceutical intermediate market. Engaging with suppliers from regions with strong chemical production, such as China, can often offer competitive pricing and scalable supply.
  • Verify Specifications: Always request a Certificate of Analysis (CoA) to confirm the product's purity (≥98.0%), CAS number (603-76-9), and other critical parameters. Ensure the packaging and storage recommendations meet your operational requirements.
  • Obtain Quotes: Contact multiple suppliers to gather price quotations. When comparing prices, always consider the overall value proposition, including quality, reliability, and customer service, not just the per-kilogram cost.
  • Ensure Regulatory Compliance: For pharmaceutical applications, understanding any regulatory documentation or support that the manufacturer can provide is crucial for smooth integration into your validated processes.

Conclusion

1-Methylindole (CAS 603-76-9) is an indispensable component in modern pharmaceutical manufacturing. By prioritizing quality sourcing and partnering with reliable manufacturers and suppliers, companies can ensure the efficient production of vital APIs like Osimertinib, contributing to advancements in healthcare.