The relentless pursuit of novel and effective pharmaceuticals drives continuous innovation in chemical synthesis. At the heart of this process lies the availability of high-quality pharmaceutical intermediates. One such compound, 13-Acetyl-9-dihydrobaccatin III (CAS 142203-65-4), stands out for its significance in the development of advanced therapies, particularly in the field of oncology. This article delves into the synthesis, properties, and essential role of this intermediate for researchers and procurement specialists.

Synthesis and Chemical Properties

13-Acetyl-9-dihydrobaccatin III is a complex organic molecule, often derived from natural sources or through intricate synthetic pathways. Its structure is a precursor to various taxane derivatives, which are renowned for their potent anti-cancer activities. Typically appearing as a white to off-white powder, its stability and reactivity are optimized for subsequent chemical transformations. Sourcing this compound from a reliable manufacturer ensures that it meets the precise chemical specifications required for complex drug synthesis, where even minor impurities can have significant downstream effects.

Applications in Pharmaceutical R&D

The primary application of 13-Acetyl-9-dihydrobaccatin III lies in its function as a key intermediate in the synthesis of Paclitaxel and its analogs. These drugs function by interfering with cell division, making them invaluable in treating a range of cancers. Researchers rely on this intermediate for:

  • Building Block for APIs: It serves as a foundational chemical structure onto which other functional groups are added to create the final Active Pharmaceutical Ingredient (API).
  • Impurity Reference Standard: High-purity batches are also utilized as reference standards for analytical testing, helping to identify and quantify impurities in drug manufacturing processes.
  • Process Optimization: Understanding the synthesis and handling of this intermediate can lead to more efficient and cost-effective drug production methods.

Procurement Considerations for Buyers

For procurement managers and R&D scientists looking to buy 13-Acetyl-9-dihydrobaccatin III, several factors are crucial: consistency in quality, competitive pricing, and a reliable supply chain. Engaging with manufacturers who specialize in pharmaceutical intermediates, particularly those with experience in supplying to the global market, is highly recommended. Companies often seek out suppliers in regions like China due to the combination of advanced manufacturing capabilities and cost efficiencies. When you purchase this intermediate, always verify the Certificate of Analysis (CoA) and inquire about bulk purchasing options to secure the best price and ensure sufficient stock for your projects.

In summary, 13-Acetyl-9-dihydrobaccatin III is more than just a chemical compound; it's a critical enabler of pharmaceutical innovation. Ensuring a stable and high-quality supply is essential for advancing drug discovery and development.