For chemists and formulation scientists, understanding the synthesis and application of key chemical intermediates is fundamental to innovation and efficient production. 2-Chloro-3-amino-4-methylpyridine, identified by CAS number 133627-45-9, is a significant compound in the realm of pharmaceutical synthesis, most notably as a precursor to Nevirapine. This article delves into its chemical properties, common synthesis pathways, and its crucial role in the pharmaceutical industry.

Chemical Profile and Properties

2-Chloro-3-amino-4-methylpyridine is characterized by its molecular formula C6H7ClN2 and a molecular weight of approximately 142.59 g/mol. As a yellowish powder, it typically exhibits a melting point in the range of 61-64°C. Its density is around 1.26 g/cm³, and it possesses a boiling point of approximately 283.3°C at atmospheric pressure. The compound is soluble in solvents like chloroform and ethanol, making it amenable to various reaction conditions.

Synthesis Routes and Industrial Production

The preparation of 2-Chloro-3-amino-4-methylpyridine can be achieved through several synthetic methodologies. One notable route involves the conversion from 2-chloro-4-methylnicotinamide. This process often utilizes reagents like calcium hypochlorite and calcium oxide under controlled temperature conditions. Detailed procedures highlight steps such as controlled addition of reagents, specific reaction temperatures (e.g., 50°C for chlorination, followed by cooling and pH adjustment), and purification methods like recrystallization to achieve high purity.

Another approach described starts from 4,4-dimethoxyl-2-butanone and cyanoacetamide. These synthesis pathways are optimized for scalability and yield, making them suitable for industrial production. For businesses looking to buy this intermediate, understanding these synthesis methods can provide insights into potential impurities and quality control measures employed by manufacturers.

Critical Application: Nevirapine Intermediate

The primary industrial application of 2-Chloro-3-amino-4-methylpyridine is its role as a key intermediate in the synthesis of Nevirapine. Nevirapine is a vital non-nucleoside reverse transcriptase inhibitor (NNRTI) that plays a critical role in the treatment of HIV-1 infections. The demand for efficient and cost-effective synthesis of Nevirapine fuels the market for high-quality 2-Chloro-3-amino-4-methylpyridine. Pharmaceutical companies and contract manufacturing organizations (CMOs) actively seek reliable suppliers of this compound.

Procurement and Supply Chain Considerations

When sourcing this essential intermediate, researchers and procurement specialists should prioritize suppliers who can guarantee consistent purity and timely delivery. Manufacturers from regions like China are significant players in the global supply of such chemicals, offering competitive pricing. For those intending to buy, engaging with established suppliers like NINGBO INNO PHARMCHEM CO., LTD. ensures access to well-characterized materials essential for pharmaceutical manufacturing. Always inquire about batch-to-batch consistency and available documentation.