For procurement managers and R&D scientists in the pharmaceutical industry, sourcing high-quality intermediates is paramount to the success of drug development and manufacturing. 2-Chloro-3-amino-4-methylpyridine (CAS: 133627-45-9) stands out as a critical building block, particularly for the synthesis of Nevirapine, an important antiretroviral medication. Understanding where to buy this compound and what to look for can significantly streamline your procurement process.

Why is 2-Chloro-3-amino-4-methylpyridine Essential?

This pyridine derivative serves as a key intermediate in the complex synthesis pathways of various Active Pharmaceutical Ingredients (APIs). Its primary application lies in the manufacturing of Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. The consistent availability of high-purity 2-Chloro-3-amino-4-methylpyridine directly impacts the efficiency and cost-effectiveness of Nevirapine production.

Key Considerations When Purchasing:

  • Purity Levels: For pharmaceutical applications, purity is non-negotiable. Look for suppliers offering 2-Chloro-3-amino-4-methylpyridine with a minimum purity of 99.0%, as indicated by HPLC analysis. This ensures that your downstream reactions proceed smoothly and that the final API meets regulatory standards.
  • Supplier Reliability: Partnering with a dependable manufacturer or supplier is crucial. Consider factors like production capacity, quality control procedures, regulatory compliance (e.g., ISO certification), and their track record in the chemical industry. Manufacturers based in China often provide competitive pricing and extensive supply capabilities.
  • Pricing and Quotation: When you are ready to buy, obtaining a detailed quotation is the next step. Compare prices from multiple reputable suppliers to ensure you are getting the best value for your investment. Factors influencing price include order volume, purity, and packaging.
  • Technical Specifications and Documentation: Always request comprehensive technical data sheets (TDS), Certificates of Analysis (CoA), and Material Safety Data Sheets (MSDS) to verify product quality and safety. For commercial manufacturing, ensure the supplier can provide necessary documentation for regulatory submissions.

Navigating the Supplier Landscape

The global market offers numerous suppliers for 2-Chloro-3-amino-4-methylpyridine. For procurement managers seeking to buy this chemical intermediate, focusing on manufacturers with established expertise in fine chemicals and pharmaceutical intermediates is advisable. Many Chinese chemical manufacturers are well-positioned to meet these demands, offering both quality and competitive pricing. Exploring options like NINGBO INNO PHARMCHEM CO., LTD. can provide access to reliable sourcing channels for this critical compound.

By prioritizing purity, supplier reliability, and thorough technical evaluation, procurement professionals can successfully secure a consistent supply of 2-Chloro-3-amino-4-methylpyridine, thereby supporting the vital production of life-saving medications like Nevirapine.