For chemical manufacturers, securing a stable and high-quality supply of key intermediates is fundamental to efficient production and product innovation. 3-Bromo-5-fluorobenzaldehyde (CAS 188813-02-7) is one such compound, playing a vital role in the synthesis of a diverse range of downstream products. Understanding its properties and market availability is crucial for strategic procurement.

The Functional Importance of 3-Bromo-5-fluorobenzaldehyde

As a versatile aromatic aldehyde, 3-Bromo-5-fluorobenzaldehyde offers significant utility due to its reactive aldehyde group and the presence of halogen substituents. These features allow it to participate in a variety of important chemical reactions:

  • Nucleophilic Addition: The aldehyde group is susceptible to nucleophilic attack, enabling reactions like Grignard reactions, Wittig reactions, and reductive aminations, which are foundational in creating complex organic molecules.
  • Electrophilic Aromatic Substitution: While the existing substituents influence reactivity, the aromatic ring can still undergo further modifications under appropriate conditions.
  • Cross-Coupling Reactions: The bromine atom serves as an excellent leaving group in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig couplings), allowing for the formation of new carbon-carbon or carbon-heteroatom bonds.

These reactions are critical for manufacturers producing fine chemicals, pharmaceutical intermediates, and materials for the electronics industry. For instance, it is a documented intermediate in the synthesis of molecules like 3,4-diamino-3-cyclobutene-1,2-diones and 9,10-Dihydro-9,10-diboraanthracenes.

What Manufacturers Need to Know When Buying

When chemical manufacturers decide to buy 3-Bromo-5-fluorobenzaldehyde, they prioritize factors that ensure seamless integration into their production lines:

  • Consistent Specifications: Reliable purity (typically ≥97%), consistent appearance (white to yellow powder), and a stable melting point (41-43°C) are essential for predictable reaction outcomes.
  • Scalability of Supply: Manufacturers need assurance that their supplier can meet their production volumes, from pilot scale to full commercial production.
  • Cost-Effectiveness: Competitive pricing, especially for bulk purchases, directly impacts the profitability of the final product.
  • Regulatory Compliance: Understanding and ensuring compliance with relevant chemical regulations (like REACH or local safety standards) is crucial.

Partnering with a Chinese Manufacturer

NINGBO INNO PHARMCHEM CO.,LTD. is a premier chemical manufacturer in China dedicated to providing high-quality 3-Bromo-5-fluorobenzaldehyde. We offer reliable supply, competitive pricing, and adhere to stringent quality control measures. For manufacturers looking to secure a steady source of this vital intermediate, we invite you to contact us for a quote and to discuss how our product can support your manufacturing needs.