In the realm of fine chemicals and organic synthesis, understanding the specific properties and synthesis routes of key intermediates is crucial for researchers and industrial chemists alike. 3-Bromo-5-fluorobenzaldehyde (CAS 188813-02-7) is one such compound, valued for its unique chemical structure and reactivity. This article explores its essential characteristics and manufacturing insights, providing valuable information for those looking to purchase or utilize it.

Chemical Profile of 3-Bromo-5-fluorobenzaldehyde

3-Bromo-5-fluorobenzaldehyde is an aromatic aldehyde that belongs to the class of halogenated benzaldehydes. Its molecular formula is C7H4BrFO, and it has a molecular weight of approximately 203.01 g/mol. The compound is characterized by:

  • Appearance: Typically a white to yellow crystalline powder. The exact shade can vary slightly depending on the manufacturing batch and purity.
  • Melting Point: Its reported melting point is in the range of 41-43°C. This relatively low melting point means it can sometimes be encountered as a semi-solid or liquid if ambient temperatures are warm.
  • Purity: For most demanding applications in organic synthesis, a purity of 97% to 98% is commonly specified. High purity is essential to ensure the success of subsequent reactions and to avoid unwanted byproducts.
  • Solubility: It is described as slightly soluble in water, but generally soluble in common organic solvents like ethanol, ether, and chlorinated solvents, which are typical for aromatic compounds of this nature.
  • Storage: Due to potential light sensitivity, it is often recommended to store 3-Bromo-5-fluorobenzaldehyde under an inert atmosphere and in a cool, dry place, typically between 2-8°C, to maintain its stability and quality over time.

Synthesis Insights

The synthesis of 3-Bromo-5-fluorobenzaldehyde typically involves controlled halogenation and functionalization of aromatic precursors. While specific proprietary methods vary among manufacturers, general approaches might include:

  • Starting from a suitably substituted benzene derivative (e.g., 1,3-difluoro-5-bromobenzene or a related compound).
  • Introducing the aldehyde group through methods like formylation (e.g., Vilsmeier-Haack reaction or Gattermann-Koch synthesis) or oxidation of a corresponding benzyl alcohol.
  • Careful control of reaction conditions, catalysts, and purification steps (such as column chromatography or recrystallization) are vital to achieve high yields and purity.

Procurement and Supply

For businesses requiring 3-Bromo-5-fluorobenzaldehyde, identifying reliable manufacturers who can consistently deliver this compound with the specified properties is key. NINGBO INNO PHARMCHEM CO.,LTD. is a leading supplier and manufacturer in China, offering this intermediate with guaranteed quality and competitive pricing. We provide detailed technical specifications and are equipped to handle inquiries for bulk orders. To buy this essential chemical for your synthesis needs, contact us to discuss your requirements and obtain a quote.