In the realm of pharmaceutical chemistry, certain compounds serve as indispensable building blocks for life-saving medications. One such critical intermediate is 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline, identified by CAS number 74852-62-3. This heterocyclic amine is a vital precursor in the synthesis of Itraconazole, a broad-spectrum antifungal agent used globally to treat a variety of fungal infections. For researchers and pharmaceutical companies, understanding the properties and sourcing of this intermediate is key to successful drug development and manufacturing.

Chemical Profile and Properties

4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline is characterized by its molecular formula C17H21N3O and a molecular weight of approximately 283.37 g/mol. Sourced from trusted manufacturers, it typically presents as a Dark Purple to Dark Grey Solid with a high purity level, often exceeding 95% as verified by HPLC. Its melting point is approximately 186°C, indicating its solid state under standard conditions. The compound is noted to be stable under normal temperatures and pressures, which simplifies its handling and storage. When considering where to purchase this compound, reputable chemical suppliers in China are a primary source, offering competitive pricing and reliable availability.

Application in Itraconazole Synthesis

The primary application of 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline is its role as a key intermediate in the multi-step synthesis of Itraconazole. Itraconazole is a triazole antifungal that works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. The specific structural features of 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline are crucial for building the complex molecular architecture of Itraconazole. Pharmaceutical companies rely on consistent access to this intermediate to ensure uninterrupted production of this important antifungal medicine.

Sourcing Strategies for Researchers and Manufacturers

When seeking to buy 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline, it is essential to partner with reliable chemical suppliers. As a specialized pharmaceutical intermediate, quality and consistency are paramount. Many leading chemical companies in China specialize in producing and supplying such compounds, often providing detailed specifications, safety data sheets (SDS), and certificates of analysis. For bulk requirements or specific purity grades, direct engagement with a manufacturer is recommended to discuss pricing and logistics. Exploring options for both small research quantities and large-scale industrial supply is advised.

The availability of this intermediate from reputable chemical suppliers allows researchers to advance their studies in antifungal therapy and enables pharmaceutical manufacturers to produce Itraconazole efficiently. By focusing on quality and a secure supply chain, professionals can confidently source 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline for their critical applications.