Urokinase, a serine protease, plays a critical role in the fibrinolytic system, facilitating the breakdown of blood clots. Dysregulation of urokinase activity is implicated in various pathological conditions, making it a significant target in medical research and drug development. 4-Aminobenzamidine dihydrochloride (CAS 2498-50-2), a chemical compound widely recognized for its inhibitory properties, also demonstrates a notable effect on urokinase, making it an important reagent for researchers in this field.

Understanding Urokinase and Its Inhibition

Urokinase plasminogen activator (uPA) converts plasminogen to plasmin, the primary enzyme responsible for fibrinolysis. While urokinase is essential for maintaining vascular health, its aberrant activity can contribute to conditions like excessive bleeding or, conversely, the progression of diseases where abnormal fibrinolysis is a factor, such as cancer metastasis. Researchers often utilize specific inhibitors to study the intricate mechanisms of urokinase action and to develop therapeutic strategies.

4-Aminobenzamidine Dihydrochloride as a Urokinase Inhibitor

4-Aminobenzamidine dihydrochloride is classified as a relatively weak, yet significant, inhibitor of urokinase. Its inhibitory constant (Ki) is typically reported in the micromolar range, indicating its capacity to modulate urokinase activity in experimental settings. While it also acts as a potent trypsin inhibitor, its dual inhibitory profile makes it a versatile compound for researchers investigating proteolytic pathways. When scientists look to buy 4-Aminobenzamidine dihydrochloride for urokinase-related studies, they are seeking a reliably sourced reagent that can provide consistent inhibitory effects.

Research Applications and Procurement Insights

The utility of 4-Aminobenzamidine dihydrochloride in urokinase research includes:

  • Mechanistic Studies: Investigating the structure-activity relationship of urokinase and developing more potent, selective inhibitors.
  • Assay Development: Establishing and validating assays for measuring urokinase activity or screening for novel urokinase modulators.
  • Preclinical Research: Exploring the therapeutic potential of modulating urokinase activity in various disease models.

For researchers and procurement managers, securing a high-quality source for 4-Aminobenzamidine dihydrochloride is paramount. Key considerations when you purchase this chemical include:

  • Purity: Aim for a minimum of 98% HPLC purity to ensure accurate and reproducible experimental outcomes.
  • Supplier Reputation: Partner with established chemical manufacturers and suppliers known for their quality control and reliable delivery.
  • Technical Documentation: Access to Certificates of Analysis (CoA) and Safety Data Sheets (SDS) is crucial.
  • Competitive Pricing: Especially for ongoing research projects, competitive pricing for 4-Aminobenzamidine dihydrochloride can be a significant factor.

As a dedicated supplier of high-purity biochemicals, we are equipped to meet the demands of researchers studying urokinase inhibition and related enzymatic pathways. We offer 4-Aminobenzamidine dihydrochloride with guaranteed quality and reliable availability. We encourage you to reach out to us for quotes and to learn more about how our products can support your vital research endeavors.