The pharmaceutical industry thrives on the precise construction of complex molecules, and key intermediates play a crucial role in this process. 4-Bromo-1-fluoro-2-iodobenzene (CAS 116272-41-4) is one such compound, a versatile building block that empowers drug discovery and development. Its unique structure, featuring three different halogen atoms on a benzene ring, offers chemists a powerful tool for creating novel APIs and therapeutic agents. Understanding its applications and sourcing reliably are vital for pharmaceutical research and manufacturing.

Understanding the Chemical Profile

4-Bromo-1-fluoro-2-iodobenzene is a halogenated aromatic compound with the molecular formula C6H3BrFI and a molecular weight of 300.89. Its structure provides multiple sites for selective chemical modification. The presence of fluorine, bromine, and iodine atoms allows for participation in various cross-coupling reactions, which are cornerstone methodologies in modern organic synthesis for forming carbon-carbon bonds. These reactions are indispensable for building the complex molecular architectures required for biologically active compounds.

Key Roles in Pharmaceutical Synthesis

As a pharmaceutical intermediate, 4-Bromo-1-fluoro-2-iodobenzene is instrumental in:

  • API Synthesis: It serves as a starting material or key intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs). Its reactive sites allow for the introduction of various functional groups necessary for a drug's therapeutic effect.
  • Drug Discovery: Researchers utilize it to synthesize diverse libraries of compounds for screening potential new drug candidates. The ability to selectively modify the halogen positions enables the creation of structurally varied molecules.
  • Development of Complex Molecules: Many modern pharmaceuticals possess intricate ring systems and functional group arrangements that can be efficiently built using precursors like this compound.

When sourcing this chemical, professionals often look for a guaranteed purity of at least 97% to ensure the integrity and reproducibility of their synthetic pathways. Storage conditions, such as maintaining a cool, dry environment and keeping containers sealed to prevent light and moisture exposure, are also critical for preserving its quality.

Finding Reliable Suppliers

For pharmaceutical companies and research institutions, identifying a trustworthy 4-Bromo-1-fluoro-2-iodobenzene supplier is crucial. Partnering with a reputable manufacturer in China can offer access to high-quality intermediates at competitive prices. When you seek to buy 4-Bromo-1-fluoro-2-iodobenzene, it’s important to look for suppliers who provide comprehensive product documentation, including Certificates of Analysis (CoA), and demonstrate a commitment to quality control. A consistent and stable supply chain is also a key consideration for ongoing manufacturing processes.

By carefully selecting your chemical suppliers, you ensure that your pharmaceutical development projects are supported by the highest quality intermediates. This allows your research teams to focus on innovation and the creation of life-saving medicines, confident in the reliability of their raw materials.

In summary, 4-Bromo-1-fluoro-2-iodobenzene (CAS 116272-41-4) is a vital component in the pharmaceutical synthesis landscape. Prioritizing purity and reliable sourcing from experienced manufacturers, particularly those based in China, ensures that the complex demands of drug development can be met efficiently and effectively.