The pharmaceutical industry continuously seeks innovative molecules to develop new therapies and improve existing treatments. Central to this pursuit are versatile chemical intermediates that act as building blocks for complex Active Pharmaceutical Ingredients (APIs). 4-Bromo-2-fluorobenzonitrile (CAS: 105942-08-3) has emerged as a highly valuable intermediate, playing a significant role in the synthesis of various drug candidates.

The Importance of 4-Bromo-2-fluorobenzonitrile in Drug Discovery

This organic compound, also known as 2-fluoro-4-bromobenzonitrile, possesses a unique chemical structure that makes it an indispensable tool for medicinal chemists. The presence of fluorine and bromine atoms, along with the nitrile group, allows for diverse chemical transformations. This versatility enables the synthesis of a wide range of pharmacologically active molecules, including compounds with potential anticancer, antiviral, and antifungal properties.

  • Structural Versatility: The bromine atom can be readily substituted or used in coupling reactions (e.g., Suzuki, Sonogashira couplings) to introduce complex aromatic or heterocyclic moieties.
  • Fluorine Substitution: The fluorine atom can influence the metabolic stability, lipophilicity, and binding affinity of the final drug molecule, often enhancing its therapeutic profile.
  • Nitrile Group Reactivity: The nitrile group can be converted into various functional groups, such as amines, carboxylic acids, or amides, further expanding its utility in drug synthesis.

Researchers frequently leverage 4-bromo-2-fluorobenzonitrile to construct novel molecular scaffolds that target specific biological pathways or receptors, accelerating the drug discovery process.

Procurement of High-Quality Pharmaceutical Intermediates

For pharmaceutical R&D departments and contract manufacturing organizations (CMOs), obtaining a consistent supply of high-purity 4-bromo-2-fluorobenzonitrile is crucial. The purity of the intermediate directly impacts the yield, purity, and safety of the API. Therefore, partnering with a reliable manufacturer and supplier is paramount.

Key considerations when looking to buy 4-bromo-2-fluorobenzonitrile include:

  • Purity Standards: Typically, a purity of ≥98.0% is required for pharmaceutical applications.
  • Supplier Reliability: Choosing a manufacturer with a proven track record in producing high-quality intermediates.
  • Batch Consistency: Ensuring that each batch meets the same stringent specifications.
  • Competitive Pricing: Cost-effectiveness is vital for managing R&D budgets.

NINGBO INNO PHARMCHEM CO.,LTD. is a premier supplier of 4-bromo-2-fluorobenzonitrile, dedicated to meeting the exacting standards of the pharmaceutical industry. We offer high-purity material, consistent quality, and competitive pricing, making us an ideal partner for your drug discovery and development projects. We invite you to inquire about our product and discuss your bulk purchasing needs. Our expertise ensures you receive a reliable supply of this critical pharmaceutical intermediate.