In the expansive field of organic chemistry, specific molecular structures serve as foundational elements for creating a vast array of complex compounds. 4-Bromo-2-fluorobenzonitrile (CAS: 105942-08-3) is one such pivotal intermediate, valued for its utility in pharmaceuticals, agrochemicals, and material science. This article explores its synthesis pathways and broad applications, emphasizing the importance of sourcing from expert chemical suppliers.

Understanding 4-Bromo-2-fluorobenzonitrile

Also recognized as 2-fluoro-4-bromobenzonitrile, this compound is characterized by a benzonitrile ring substituted with both a bromine atom and a fluorine atom. This unique arrangement of functional groups makes it a highly versatile reagent in organic synthesis. Its physical properties typically include a white to off-white crystalline powder appearance, with a defined melting point and solubility in common organic solvents.

Synthesis Methods for 4-Bromo-2-fluorobenzonitrile

Several methods can be employed for the synthesis of 4-bromo-2-fluorobenzonitrile, often involving electrophilic aromatic substitution or functional group transformations. Common approaches include:

  • Bromination of 2-Fluorobenzonitrile: A prevalent method involves the reaction of 2-fluorobenzonitrile with a brominating agent, such as bromine, in the presence of a Lewis acid catalyst (e.g., aluminum trichloride). This process selectively introduces a bromine atom onto the benzene ring at the para position relative to the nitrile group.
  • Functional Group Conversion: Alternative routes might involve starting with a precursor such as 4-bromo-2-fluorobenzoic acid, converting it to an acid chloride, and subsequently reacting it with a cyanide source to form the nitrile.

Each synthesis route requires careful control of reaction conditions, temperature, and reagent ratios to ensure high yield and purity of the final product. For commercial production, efficiency and cost-effectiveness are key considerations.

Diverse Applications in Chemical Synthesis

The value of 4-bromo-2-fluorobenzonitrile lies in its broad applicability as an intermediate:

  • Pharmaceuticals: It is extensively used in the synthesis of Active Pharmaceutical Ingredients (APIs), contributing to the development of novel drugs for various therapeutic areas.
  • Agrochemicals: This compound is a precursor for creating effective herbicides and pesticides essential for modern agriculture.
  • OLED Materials: Its structure is beneficial for synthesizing components used in advanced electronic displays, such as OLEDs.
  • Fine Chemical Synthesis: It serves as a fundamental building block for numerous other specialized organic chemicals, including heterocyclic compounds and aryl halides.

For researchers and procurement specialists, obtaining high-purity 4-bromo-2-fluorobenzonitrile (CAS: 105942-08-3) is critical. The reliability of a supplier, their manufacturing expertise, and the assurance of consistent quality are paramount.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading supplier of 4-bromo-2-fluorobenzonitrile, offering high-purity material with excellent batch consistency. Our commitment to quality and competitive pricing makes us an ideal partner for your organic synthesis needs. We invite you to contact us to buy 4-bromo-2-fluorobenzonitrile and to learn more about how we can support your chemical sourcing requirements. Our team is ready to provide quotes and discuss bulk orders to facilitate your research and production endeavors.