The world of chemical synthesis relies on a robust toolkit of versatile building blocks that enable the construction of complex molecules. Among these, 4-Bromo-2-methoxypyridine (CAS: 100367-39-3) stands out due to its unique structural features and broad utility. This compound is a vital intermediate in organic synthesis, pharmaceutical development, and potentially in material science. This article delves into its properties, synthesis, applications, and the importance of sourcing from reputable chemical manufacturers.

4-Bromo-2-methoxypyridine is characterized by a pyridine ring substituted with a bromine atom at the 4-position and a methoxy group at the 2-position. This specific substitution pattern dictates its chemical behavior. The bromine atom is an excellent leaving group, making the molecule highly reactive in palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Heck, and Sonogashira couplings. These reactions are fundamental for creating new carbon-carbon bonds, a cornerstone of complex molecule synthesis. The methoxy group, an electron-donating substituent, can influence the reactivity of the pyridine ring and guide further functionalization.

The synthesis of 4-Bromo-2-methoxypyridine typically involves regioselective bromination of 2-methoxypyridine. Methods employing reagents like N-bromosuccinimide (NBS) are common, aiming for high purity and yield. Other synthetic routes may involve functional group interconversions or directed metalation strategies. For researchers and industrial chemists, accessing this compound with high purity (often ≥99.0%) is crucial for ensuring the success and reproducibility of their synthetic endeavors. When considering where to buy this chemical, prioritizing a trustworthy supplier is key.

The applications of 4-Bromo-2-methoxypyridine are diverse and impactful. In the pharmaceutical industry, it serves as a critical intermediate for the synthesis of numerous drug candidates. It plays a pivotal role in the construction of heterocyclic systems like imidazo[1,2-a]pyrimidines and substituted pyridones, which are frequently found in drugs targeting various therapeutic areas, including cancer, inflammation, and infectious diseases. Its utility also extends to the agrochemical sector, where it is used in the development of novel pesticides and herbicides. The ability to purchase this compound at a competitive price from a reliable source is essential for R&D departments and manufacturing units.

Beyond its established roles, the compound's structure also suggests potential applications in material science. Its reactive sites could be exploited for the creation of functional polymers or as components in supramolecular assemblies. The pyridine nitrogen atom can participate in coordination chemistry, and the bromine atom allows for further modification and integration into larger molecular architectures.

For any laboratory or industrial process requiring 4-Bromo-2-methoxypyridine, verifying its CAS number (100367-39-3) and purity specifications is a standard procedure. The physical characteristics, such as its appearance as a light yellow solid, are also noted for safe handling and storage.

In conclusion, 4-Bromo-2-methoxypyridine is a valuable and versatile chemical intermediate. Its critical role in modern synthetic methodologies, particularly in the pharmaceutical and agrochemical industries, makes it an essential component for chemical innovation. By understanding its properties, synthesis, and applications, and by partnering with experienced chemical manufacturers, researchers can effectively leverage this compound to drive scientific progress.