For researchers and R&D scientists in organic chemistry, the availability of versatile and reactive intermediates is crucial for pushing the boundaries of molecular design. 4-Bromofluorobenzene (CAS 460-00-4) is a compound that consistently proves its value, offering a unique combination of reactivity that facilitates complex synthetic pathways essential for drug discovery, material science, and agrochemical development.

The Chemical Reactivity of 4-Bromofluorobenzene

4-Bromofluorobenzene (also known as 1-Bromo-4-fluorobenzene) is characterized by its benzene ring functionalized with both a fluorine atom and a bromine atom in the para positions. This structure provides two primary points of chemical utility:

  • The Carbon-Bromine Bond: This bond is highly amenable to a variety of metal-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. These reactions are indispensable for forming new carbon-carbon bonds, allowing for the construction of larger, more complex organic frameworks. For example, a researcher might use a Suzuki coupling to attach a boronic acid to the brominated position, introducing a new aromatic or heterocyclic substituent.
  • The Carbon-Fluorine Bond: While generally less reactive than the C-Br bond, the C-F bond can be activated under specific conditions and its presence influences the overall electronic properties and stability of the molecule. Fluorine incorporation is a common strategy in medicinal chemistry to modulate properties like lipophilicity, metabolic stability, and binding affinity.
  • Grignard Reagent Formation: Treatment of 4-Bromofluorobenzene with magnesium metal forms the corresponding Grignard reagent, 4-fluorophenylmagnesium bromide. This organometallic species is a potent nucleophile and a powerful tool for introducing the 4-fluorophenyl moiety into carbonyl compounds, epoxides, or other electrophiles, leading to a wide array of functionalized products.

Applications in Research and Development

The versatility of 4-Bromofluorobenzene makes it valuable in numerous research areas:

  • Pharmaceutical Discovery: It is used to synthesize novel drug candidates, particularly those requiring a fluorophenyl group or complex aromatic structures.
  • Agrochemical Innovation: It serves as an intermediate in developing new pesticides and crop protection agents with enhanced efficacy and targeted action.
  • Material Science: Its derivatives can be used in the synthesis of advanced materials, such as liquid crystals or organic electronic components.
  • Academic Research: It is a standard reagent for teaching and exploring fundamental organic reactions and synthetic strategies.

Sourcing for Your Research Projects

For scientists needing to buy 4-Bromofluorobenzene for their research, sourcing from reliable manufacturers is key. Look for suppliers who offer high purity (e.g., 99%+), provide detailed analytical data (CoA, NMR, GC-MS), and can offer competitive pricing for research quantities or larger developmental batches. Manufacturers in China are often excellent sources for such intermediates. We encourage you to contact us to inquire about the availability and pricing of 4-Bromofluorobenzene to support your ongoing research and development endeavors.