The pharmaceutical industry's relentless pursuit of novel therapeutics hinges on the availability of high-quality chemical building blocks. Among these, 4-Fluorophenylacetic Acid (CAS 405-50-5) stands out as a crucial intermediate, underpinning the synthesis of a diverse range of pharmacologically active compounds. For procurement specialists and research scientists, understanding its applications and sourcing channels is vital for successful drug development.

The Significance of 4-Fluorophenylacetic Acid in Pharmaceuticals

4-Fluorophenylacetic Acid, with the chemical formula C8H7FO2, is a phenylacetic acid derivative characterized by a fluorine atom on the phenyl ring. This structural feature imparts unique properties that can enhance a drug candidate's efficacy, stability, and metabolic profile. Its primary role is as a pharmaceutical intermediate, meaning it's a key component used in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs).

Key Pharmaceutical Applications:

  • Fluorinated Anesthetics: A significant application of 4-Fluorophenylacetic Acid is in the synthesis of fluorinated anesthetics. These compounds are indispensable in modern medicine for providing pain relief and sedation during surgical procedures, directly contributing to patient safety and recovery.
  • Receptor Antagonists: Research indicates its use in developing highly potent and selective antagonists for human A2B adenosine receptors. Targeting these receptors is a promising avenue for treating various inflammatory diseases and other conditions.
  • Antiviral Agents: The compound also plays a role in synthesizing antagonists for human CCR5 receptors, which are key targets in the development of anti-HIV-1 therapies.
  • NSAID Synthesis: It is also utilized as a building block in the synthesis of certain Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), where the fluorine atom can modulate efficacy and pharmacokinetic properties.

Effective Sourcing Strategies for Buyers

When procurement managers look to buy 4-Fluorophenylacetic Acid, they must prioritize reliable suppliers that can guarantee consistent purity and quality. Key considerations include:

  • Purity Standards: Aim for suppliers offering a purity of 98% or higher, with documented analytical data.
  • Supplier Reputation: Choose manufacturers with a proven track record in producing and supplying pharmaceutical intermediates. Manufacturers based in China, like NINGBO INNO PHARMCHEM CO.,LTD., are often major suppliers.
  • Regulatory Compliance: Ensure the supplier can provide necessary documentation, including Safety Data Sheets (SDS) and certificates of analysis, to meet your internal quality and regulatory requirements.
  • Competitive Pricing: While quality is paramount, competitive pricing is also essential for managing project budgets. Request quotes from multiple verified suppliers.

Conclusion: Securing Your Supply Chain

4-Fluorophenylacetic Acid (CAS 405-50-5) is an indispensable component in the modern pharmaceutical synthesis toolkit. By understanding its applications and employing strategic sourcing practices, research organizations and pharmaceutical manufacturers can ensure a steady supply of this vital intermediate, accelerating the development and delivery of new medicines.