The chemical industry thrives on the precise synthesis of complex molecules, often relying on versatile intermediate compounds. 4-Fluorophenylacetonitrile (CAS 459-22-3) has emerged as a compound of significant interest, particularly within the pharmaceutical sector, due to its essential role in the production of critical medications. This article explores the chemical properties, key applications, and sourcing considerations for this important intermediate.

Chemically classified as a benzene acetonitrile derivative, 4-Fluorophenylacetonitrile is characterized by its fluorinated phenyl group attached to an acetonitrile moiety. This structure imparts unique reactivity, making it a valuable building block in organic synthesis. Its physical form is typically a clear colorless to light yellow liquid, with a high assay, commonly exceeding 98.0%. These specifications are crucial for researchers and formulators who require high purity for downstream reactions and product efficacy.

The most prominent application of 4-Fluorophenylacetonitrile lies in its use as a precursor for Aprepitant. Aprepitant is a neurokinin-1 (NK-1) receptor antagonist widely prescribed to prevent chemotherapy-induced nausea and vomiting (CINV). The synthesis pathway for Aprepitant highlights the importance of intermediates like 4-Fluorophenylacetonitrile, underscoring the need for a stable and reliable supply chain. Beyond pharmaceuticals, its chemical structure lends itself to broader applications in fine chemical synthesis, catering to various specialized industries.

For companies looking to buy 4-Fluorophenylacetonitrile, partnering with established manufacturers, especially those based in China, offers a pathway to obtaining high-quality material at competitive prices. When sourcing, it is advisable to thoroughly vet potential suppliers, ensuring they meet rigorous quality standards and can provide necessary documentation. Understanding the product's specifications, such as CAS number and purity, is fundamental to making an informed purchasing decision.

In conclusion, 4-Fluorophenylacetonitrile is a critical component in the modern chemical landscape, enabling the production of life-saving drugs and facilitating advanced organic synthesis. By prioritizing quality and reliable sourcing from reputable suppliers, industries can harness the full potential of this versatile chemical intermediate.