The world of chemical synthesis relies heavily on a diverse range of intermediates that act as fundamental building blocks for more complex molecules. 4-Methoxyphenylethylamine (CAS 55-81-2) is one such compound, playing a significant role, particularly in the pharmaceutical sector. This article delves into the chemical synthesis aspects of this intermediate, discussing its properties, applications, and the practicalities of sourcing it from manufacturers and suppliers.

The Chemical Profile of 4-Methoxyphenylethylamine

Characterized by CAS number 55-81-2, 4-Methoxyphenylethylamine is an organic compound with the molecular formula C9H13NO and a molecular weight of 151.21. It presents as a clear, colorless to slightly yellow liquid, commonly supplied at a purity level of 97% or higher. Key physical properties such as its boiling point (138-140 °C at 20 mmHg) and density contribute to its handling characteristics in laboratory and industrial settings. The presence of a primary amine group and a methoxy-substituted aromatic ring makes it a versatile reactant in various organic transformations.

Applications in Chemical Synthesis and Beyond

The most prominent application for 4-Methoxyphenylethylamine is its use as an intermediate in the synthesis of ritodrine. Ritodrine is a well-known tocolytic agent used in obstetrics to manage preterm labor. The demand for this pharmaceutical highlights the importance of a consistent and reliable supply of 4-Methoxyphenylethylamine. Beyond its pharmaceutical role, this compound can serve as a valuable building block in broader organic synthesis. Its reactive amine group and aromatic structure allow for a range of modifications, making it useful for researchers exploring new chemical entities or developing novel synthetic routes.

Sourcing 4-Methoxyphenylethylamine: Manufacturers and Suppliers

For chemical synthesis projects, whether in academic research or industrial manufacturing, securing a dependable source of 4-Methoxyphenylethylamine is essential. Manufacturers and suppliers in China are a primary resource for this intermediate, often offering competitive pricing and a broad spectrum of purity grades. When engaging with suppliers, it is crucial to request detailed product specifications, including purity analysis and safety data. Many companies also provide samples, allowing researchers to evaluate the material's suitability for their specific reactions before making larger purchases.

Procurement Considerations for Industry Professionals

Procurement managers and R&D scientists should focus on partnering with suppliers who demonstrate a commitment to quality and consistency. Factors to consider include the supplier's experience, their quality control processes, and their ability to provide timely deliveries. Understanding the price point in relation to purity is also important. Bulk purchasing from manufacturers can often lead to significant cost savings, making it an attractive option for larger-scale synthesis projects. It is advisable to obtain multiple quotes and compare the overall value proposition offered by different suppliers.

Conclusion

4-Methoxyphenylethylamine (CAS 55-81-2) is a critical chemical intermediate with established applications in pharmaceutical synthesis, notably for ritodrine. Its utility also extends to general organic synthesis, offering chemists a versatile building block. By carefully selecting manufacturers and suppliers, emphasizing purity and reliability, and strategically managing procurement, industries can ensure a stable and cost-effective supply of this valuable compound, thereby facilitating advancements in chemical research and drug development.