In the competitive landscape of the chemical and pharmaceutical industries, a thorough understanding of chemical intermediates is crucial for successful product development and manufacturing. 4-Methoxyphenylethylamine, identified by CAS number 55-81-2, is a key compound that warrants detailed examination regarding its properties and sourcing strategies. This article provides insights for industry professionals seeking to procure this vital chemical, with a particular focus on its characteristics and how to engage with manufacturers and suppliers.

Chemical Identity and Properties of 4-Methoxyphenylethylamine

4-Methoxyphenylethylamine, with the molecular formula C9H13NO and a molecular weight of 151.21, is recognized for its role as a pharmaceutical intermediate. Its physical appearance is typically described as a clear, colorless to slightly yellow liquid. Key physical properties include a boiling point of 138-140 °C at 20 mmHg, a density of 1.031 g/mL at 20 °C, and a flash point exceeding 230 °F. A stated purity of 97%+ is common, underscoring its suitability for sensitive synthesis applications. The chemical's pKa value of approximately 9.96 indicates its basic nature, typical for primary amines.

Primary Application: Ritodrine Synthesis

The most significant industrial application of 4-Methoxyphenylethylamine is as a precursor in the synthesis of ritodrine. Ritodrine is a medication belonging to the class of beta-2 adrenergic agonists, used clinically to inhibit premature uterine contractions and prevent preterm birth. The reliable supply of high-purity 4-Methoxyphenylethylamine is therefore directly linked to the availability of this critical therapeutic agent. Researchers and pharmaceutical manufacturers rely on consistent access to this intermediate for their production needs.

Sourcing Strategies: Finding Manufacturers and Suppliers

For companies looking to buy 4-Methoxyphenylethylamine, identifying dependable sources is a primary concern. Manufacturers and suppliers in China are prominent players in the global chemical market, offering competitive pricing and a wide range of intermediates. When selecting a supplier, it is essential to look for evidence of quality control, such as ISO certifications and detailed product documentation like Certificates of Analysis (CoA). Engaging directly with manufacturers can often streamline the procurement process and provide opportunities for better pricing, especially for bulk orders.

Factors to Consider for Purchase Decisions

When making purchasing decisions for 4-Methoxyphenylethylamine, consider the purity specifications required for your application, as well as the supplier's reliability and lead times. Many Chinese manufacturers offer samples, which is an excellent way to verify product quality and suitability before committing to larger quantities. Understanding the price per kilogram and comparing offers from multiple reputable suppliers will help ensure you secure the best value for your investment. It's also beneficial to inquire about packaging options suitable for transport and storage.

Conclusion

4-Methoxyphenylethylamine (CAS 55-81-2) is an important chemical intermediate with clear utility in the pharmaceutical industry, particularly for the synthesis of ritodrine. By understanding its chemical and physical properties and adopting a strategic approach to sourcing from reputable manufacturers and suppliers, especially in China, businesses can ensure a reliable and cost-effective supply. Prioritizing quality and due diligence in supplier selection will pave the way for successful research and manufacturing outcomes.