In the dynamic landscape of chemical manufacturing, understanding the precise properties and reliable sourcing of intermediates is crucial for success. This article focuses on 5,6,7,8-Tetrahydro-2-naphthol, a significant organic compound identified by its CAS number 1125-78-6. We will explore its key physical and chemical characteristics, its primary applications, and the benefits of engaging with manufacturers and suppliers, particularly those based in China.

Key Physical and Chemical Properties

5,6,7,8-Tetrahydro-2-naphthol (often referred to by synonyms such as 6-Hydroxytetralin or Tetralin-6-ol) is valued for its well-defined properties. Typically, it presents as a white crystal. Its molecular formula is C10H12O, and its molecular weight is approximately 148.202 g/mol. Important physical parameters include:

  • Melting Point: Approximately 59-61°C (lit.). This solid state at room temperature is convenient for handling and storage.
  • Boiling Point: Around 275.5°C at 760 mmHg.
  • Assay: Generally specified as ≥98.0%. This high purity is critical for its intended applications, especially in the pharmaceutical sector.
  • Appearance: White crystal. Consistency in appearance is often an initial indicator of quality.

These properties make it suitable for precise chemical reactions and synthesis processes, where predictable behavior is essential.

Applications and Manufacturing Landscape

The primary application for 5,6,7,8-Tetrahydro-2-naphthol is as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its role as a precursor in the manufacturing of Liranaftate (CAS: 88678-31-3) highlights its importance in the pharmaceutical supply chain. Beyond this, its versatile chemical structure lends itself to various research and development endeavors in organic synthesis.

The manufacturing of such specialized chemicals is often concentrated in regions with advanced chemical industries and economies of scale. China has become a significant hub for the production of fine chemicals and pharmaceutical intermediates. Companies looking to buy 5,6,7,8-Tetrahydro-2-naphthol can benefit from sourcing directly from Chinese manufacturers who offer:

  • Economies of Scale: Leading to competitive pricing for bulk orders.
  • Established Infrastructure: Facilitating efficient production and quality control.
  • Global Reach: Ensuring that high-quality materials are accessible to R&D scientists and procurement managers worldwide.

Quality Assurance and Procurement Considerations

When procuring 5,6,7,8-Tetrahydro-2-naphthol (CAS 1125-78-6), it is crucial to partner with suppliers who emphasize quality assurance. This includes providing accurate specifications, Certificates of Analysis (COAs), and transparent manufacturing practices. Procurement managers should seek suppliers who can offer stable supply, consistent quality, and competitive pricing, especially for large-scale production needs. Terms such as 'manufacturer,' 'supplier,' 'high purity,' and 'in China' are important search parameters.

In summary, the distinct physical and chemical properties of 5,6,7,8-Tetrahydro-2-naphthol, coupled with its critical role as a pharmaceutical intermediate, make it a sought-after chemical. Engaging with reputable manufacturers and suppliers, particularly from China, is key to obtaining this compound reliably and cost-effectively.