In the intricate world of organic synthesis, specific molecules stand out for their versatility and potential to unlock new chemical pathways. 5'-Fluoro-2'-iodoacetophenone, identified by CAS 914225-70-0, is one such compound. As a key player in pharmaceutical intermediate manufacturing, its unique chemical profile makes it an indispensable tool for synthetic chemists aiming to create complex organic molecules. Understanding its properties and how to effectively utilize it can significantly enhance research and development outcomes.

The Chemical Significance of 5'-Fluoro-2'-iodoacetophenone

5'-Fluoro-2'-iodoacetophenone is characterized by an acetophenone core substituted with both a fluorine atom and an iodine atom. This combination is particularly potent. The fluorine atom, known for its electronegativity, can influence the electronic properties of the molecule, often enhancing metabolic stability and target binding in biologically active compounds. The iodine atom, on the other hand, is an excellent leaving group and a versatile participant in numerous cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings. These reactions are fundamental in constructing carbon-carbon and carbon-heteroatom bonds, essential for building complex molecular frameworks.

Applications Beyond Pharmaceuticals

While its role as a pharmaceutical intermediate, particularly in the synthesis of anticancer drugs, is well-established, the utility of 5'-Fluoro-2'-iodoacetophenone extends further into general organic synthesis. Researchers exploring novel materials, agrochemicals, or fine chemicals can leverage its reactive sites to introduce specific functionalities or to build diverse chemical libraries. For instance, the iodine can be readily substituted or participate in metal-catalyzed reactions to create new aromatic or heterocyclic systems. The ketone group itself can undergo various transformations, including reductions, oxidations, and condensation reactions.

Procurement and Supplier Considerations

For laboratories and chemical companies looking to buy 5'-Fluoro-2'-iodoacetophenone, partnering with reliable suppliers is crucial. We, as a dedicated manufacturer and supplier, ensure that our product maintains high purity levels (≥98%), vital for reproducible synthetic outcomes. When seeking to purchase this chemical, consider engaging directly with manufacturers like us to obtain the best price and ensure consistent availability. Whether you need small quantities for initial research or larger volumes for pilot studies, we are equipped to meet your demands.

Advancing Your Synthesis Projects

The strategic placement of fluorine and iodine on the aromatic ring of 5'-Fluoro-2'-iodoacetophenone offers synthetic chemists a powerful tool to achieve regioselective functionalization. Its availability from reputable sources like ours means that your R&D projects can proceed without the bottleneck of sourcing critical intermediates. We are committed to supporting the broader chemical synthesis community by providing this essential building block at competitive prices. If your work involves complex organic transformations or the development of novel compounds, consider incorporating 5'-Fluoro-2'-iodoacetophenone into your synthetic strategy.