The relentless pursuit of novel and effective therapeutics drives innovation in pharmaceutical research. At the heart of this endeavor lies the synthesis of complex molecules, often requiring specialized chemical intermediates. 5'-Fluoro-2'-iodoacetophenone, identified by CAS 914225-70-0, has emerged as a compound of significant interest due to its pivotal role in the development of advanced pharmaceuticals, particularly in the field of oncology. As a manufacturer and supplier, we are proud to provide this essential building block to the global drug discovery community.

A Cornerstone in Anticancer Drug Development

The most prominent application of 5'-Fluoro-2'-iodoacetophenone is its function as a key intermediate in the synthesis of lorlatinib. Lorlatinib is a third-generation anaplastic lymphoma kinase (ALK) and ROS1 inhibitor, used to treat specific types of non-small cell lung cancer (NSCLC). The molecular architecture of lorlatinib, and indeed many targeted cancer therapies, is complex and requires precise synthetic pathways. 5'-Fluoro-2'-iodoacetophenone provides a critical structural component that allows for the necessary functionalization and chain elongation required to build the final drug molecule. Its fluorine atom can contribute to pharmacokinetic properties like metabolic stability, while the iodine atom facilitates key coupling reactions.

Versatility in Drug Discovery Programs

Beyond its established role in lorlatinib synthesis, the unique chemical features of 5'-Fluoro-2'-iodoacetophenone make it a valuable asset in broader drug discovery programs. Its halogenated aromatic ketone structure offers multiple reactive sites for chemists to explore. The iodine can be replaced or coupled via transition metal catalysis, allowing for the introduction of diverse chemical moieties. The ketone group can participate in condensation reactions or be reduced to an alcohol, further expanding the synthetic possibilities. This versatility makes it an excellent starting point for generating chemical libraries used in high-throughput screening for new drug candidates targeting various diseases.

Procuring High-Quality Intermediates

For drug discovery teams, reliable access to high-purity intermediates is non-negotiable. When you need to buy 5'-Fluoro-2'-iodoacetophenone, it is essential to source from reputable manufacturers and suppliers who can guarantee quality and consistency. We, as a dedicated producer of this compound, ensure that our product meets stringent purity standards (≥98%), which is critical for successful and reproducible drug synthesis. We understand the importance of timely delivery and consistent quality for research projects and are committed to being a dependable partner in your drug discovery efforts. If you are looking for a trusted supplier for CAS 914225-70-0, consider us for your sourcing needs.

By providing essential building blocks like 5'-Fluoro-2'-iodoacetophenone, we aim to support and accelerate the development of next-generation therapeutics, ultimately contributing to improved patient outcomes.