Acetanilide (CAS 103-84-4): Historical Antipyretic and Modern Chemical Intermediate
Acetanilide, bearing the CAS number 103-84-4, is a compound with a rich history, evolving from an early medicinal agent to a vital component in modern industrial synthesis. This white crystalline powder, chemically known as N-Phenylacetamide, was once celebrated for its ability to combat fever and pain, but its journey highlights the advancements in chemical safety and application.
In the late 19th century, acetanilide was introduced to the medical world as 'Antifebrin'. Discovered serendipitously by German physicians Arnold Cahn and Paul Hepp, it was one of the first synthetic drugs to effectively reduce fever and alleviate pain. Its efficacy was remarkable for the time, offering relief from symptoms like headaches and rheumatic pain. However, its use was eventually discontinued due to severe adverse effects. These included methemoglobinemia, a condition where the blood's oxygen-carrying capacity is reduced, leading to cyanosis, and potential damage to the liver and kidneys. These toxicities paved the way for the development of safer alternatives, most notably paracetamol, which is a metabolite of acetanilide.
While acetanilide has stepped back from direct therapeutic use, its significance in the chemical industry has not waned. It serves as a crucial intermediate in the synthesis of a broad spectrum of compounds. In the pharmaceutical sector, it remains important for creating intermediates for sulfa drugs and is involved in the synthesis of penicillin. The dye industry also relies heavily on acetanilide for producing various colorants. Additionally, it functions as an accelerator in rubber processing, improving the efficiency of vulcanization, and acts as a stabilizer in cellulose ester varnishes, protecting materials from degradation.
Understanding the chemical properties and synthesis of acetanilide is key for industries that utilize it. Its preparation from aniline, a fundamental organic reaction, underscores its accessibility. As a reliable manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality acetanilide, ensuring it meets the stringent requirements for its industrial applications. The compound's dual identity – a piece of medical history and a cornerstone of current chemical production – makes it a fascinating subject in chemistry. Whether you are looking to buy acetanilide or need it for pharmaceutical intermediate synthesis, our company is a trusted source.
In the late 19th century, acetanilide was introduced to the medical world as 'Antifebrin'. Discovered serendipitously by German physicians Arnold Cahn and Paul Hepp, it was one of the first synthetic drugs to effectively reduce fever and alleviate pain. Its efficacy was remarkable for the time, offering relief from symptoms like headaches and rheumatic pain. However, its use was eventually discontinued due to severe adverse effects. These included methemoglobinemia, a condition where the blood's oxygen-carrying capacity is reduced, leading to cyanosis, and potential damage to the liver and kidneys. These toxicities paved the way for the development of safer alternatives, most notably paracetamol, which is a metabolite of acetanilide.
While acetanilide has stepped back from direct therapeutic use, its significance in the chemical industry has not waned. It serves as a crucial intermediate in the synthesis of a broad spectrum of compounds. In the pharmaceutical sector, it remains important for creating intermediates for sulfa drugs and is involved in the synthesis of penicillin. The dye industry also relies heavily on acetanilide for producing various colorants. Additionally, it functions as an accelerator in rubber processing, improving the efficiency of vulcanization, and acts as a stabilizer in cellulose ester varnishes, protecting materials from degradation.
Understanding the chemical properties and synthesis of acetanilide is key for industries that utilize it. Its preparation from aniline, a fundamental organic reaction, underscores its accessibility. As a reliable manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality acetanilide, ensuring it meets the stringent requirements for its industrial applications. The compound's dual identity – a piece of medical history and a cornerstone of current chemical production – makes it a fascinating subject in chemistry. Whether you are looking to buy acetanilide or need it for pharmaceutical intermediate synthesis, our company is a trusted source.
Perspectives & Insights
Data Seeker X
“In the late 19th century, acetanilide was introduced to the medical world as 'Antifebrin'.”
Chem Reader AI
“Discovered serendipitously by German physicians Arnold Cahn and Paul Hepp, it was one of the first synthetic drugs to effectively reduce fever and alleviate pain.”
Agile Vision 2025
“Its efficacy was remarkable for the time, offering relief from symptoms like headaches and rheumatic pain.”