Understanding the Properties and Safety of Acetanilide (CAS 103-84-4)
Acetanilide, known by its CAS number 103-84-4, is a chemical compound with distinct physical and chemical characteristics that dictate its handling and applications. While historically recognized for its medicinal use as Antifebrin, understanding its properties is now primarily relevant for its role as a fine chemical intermediate. This discussion focuses on its key properties and the safety considerations associated with its industrial use.
Physically, acetanilide is typically described as an odorless, white crystalline solid, often appearing as flakes or powder. It has a melting point range of approximately 113-115 °C and a boiling point of around 304 °C. Its solubility profile indicates it is slightly soluble in cold water but more soluble in organic solvents such as ethanol, acetone, and diethyl ether. These physical attributes are important for its processing and formulation in industrial settings.
Chemically, acetanilide is an amide derived from aniline and acetic acid. Its structure, C8H9NO, confers specific reactivity. While stable under most conditions, it is combustible and can react with strong oxidizing agents. Historically, its medical use as an analgesic and antipyretic was linked to its metabolism in the body, primarily to paracetamol. However, the compound itself posed significant health risks. The most notorious side effect was methemoglobinemia, which impairs the blood's ability to transport oxygen. Other adverse effects included hemolytic anemia and potential damage to the liver and kidneys. These toxicities led to its discontinuation as a pharmaceutical agent.
In current industrial contexts, safety protocols are paramount when handling acetanilide. While its direct medical application has ceased, its status as a chemical intermediate necessitates careful management. Material Safety Data Sheets (MSDS) for acetanilide typically list it as harmful if swallowed (H302) and may carry warnings for skin, eye, and respiratory irritation. Standard precautions such as wearing appropriate personal protective equipment (PPE), ensuring adequate ventilation, and avoiding dust inhalation are crucial. Responsible disposal practices are also important, adhering to regulations for chemical waste.
As a reputable manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. prioritizes the safe handling and quality of acetanilide. By understanding its properties and adhering to safety guidelines, industries can effectively utilize acetanilide as a valuable intermediate in various chemical synthesis processes, from dye manufacturing to pharmaceutical precursor production.
Physically, acetanilide is typically described as an odorless, white crystalline solid, often appearing as flakes or powder. It has a melting point range of approximately 113-115 °C and a boiling point of around 304 °C. Its solubility profile indicates it is slightly soluble in cold water but more soluble in organic solvents such as ethanol, acetone, and diethyl ether. These physical attributes are important for its processing and formulation in industrial settings.
Chemically, acetanilide is an amide derived from aniline and acetic acid. Its structure, C8H9NO, confers specific reactivity. While stable under most conditions, it is combustible and can react with strong oxidizing agents. Historically, its medical use as an analgesic and antipyretic was linked to its metabolism in the body, primarily to paracetamol. However, the compound itself posed significant health risks. The most notorious side effect was methemoglobinemia, which impairs the blood's ability to transport oxygen. Other adverse effects included hemolytic anemia and potential damage to the liver and kidneys. These toxicities led to its discontinuation as a pharmaceutical agent.
In current industrial contexts, safety protocols are paramount when handling acetanilide. While its direct medical application has ceased, its status as a chemical intermediate necessitates careful management. Material Safety Data Sheets (MSDS) for acetanilide typically list it as harmful if swallowed (H302) and may carry warnings for skin, eye, and respiratory irritation. Standard precautions such as wearing appropriate personal protective equipment (PPE), ensuring adequate ventilation, and avoiding dust inhalation are crucial. Responsible disposal practices are also important, adhering to regulations for chemical waste.
As a reputable manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. prioritizes the safe handling and quality of acetanilide. By understanding its properties and adhering to safety guidelines, industries can effectively utilize acetanilide as a valuable intermediate in various chemical synthesis processes, from dye manufacturing to pharmaceutical precursor production.
Perspectives & Insights
Agile Reader One
“It has a melting point range of approximately 113-115 °C and a boiling point of around 304 °C.”
Logic Vision Labs
“Its solubility profile indicates it is slightly soluble in cold water but more soluble in organic solvents such as ethanol, acetone, and diethyl ether.”
Molecule Origin 88
“These physical attributes are important for its processing and formulation in industrial settings.”