Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting motor control, and its complexity continues to drive extensive research efforts. A significant area of focus involves understanding genetic risk factors, among which mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are the most prevalent cause of familial PD and a major contributor to sporadic forms of the disease. This has firmly established LRRK2 as a key therapeutic target for developing novel PD treatments.

The rationale behind targeting LRRK2 stems from the observation that increased kinase activity, particularly due to common mutations like G2019S, can lead to neuronal dysfunction and death. By developing inhibitors that can selectively reduce LRRK2 activity, researchers aim to restore normal cellular function and protect dopaminergic neurons, which are progressively lost in PD patients. This approach holds considerable promise for disease modification rather than just symptomatic relief.

N-(2-(2-(2-Methoxy-4-Morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)Methanesulfonamide (CAS 1191911-26-8) is a highly valuable compound in this research landscape. It is characterized by its potent inhibition of LRRK2, with IC50 values in the low nanomolar range for both the wild-type and G2019S mutant forms of the enzyme. Crucially, it demonstrates a favorable selectivity profile, showing minimal activity against a broad panel of other kinases. Furthermore, its ability to penetrate cell membranes allows for effective evaluation in cellular models, where it has been shown to mitigate LRRK2-driven neurotoxicity in cultured neurons.

For scientists dedicated to unraveling the complexities of Parkinson's disease and developing potential therapies, securing a reliable supply of high-quality research chemicals is paramount. As a leading manufacturer and supplier in China, we are committed to providing researchers with essential compounds like N-(2-(2-(2-Methoxy-4-Morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)Methanesulfonamide. We understand the critical importance of purity and consistency in research outcomes. Therefore, we ensure that our product meets rigorous quality standards.

We invite researchers to purchase this potent LRRK2 inhibitor from us. Our dedication to quality, coupled with competitive pricing, makes us an ideal partner for your PD research. As a manufacturer, we ensure a stable supply chain and can cater to various quantity requirements. If you are looking to buy N-(2-(2-(2-Methoxy-4-Morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)Methanesulfonamide, consider us your trusted source. Obtaining a quote from our company is straightforward and provides access to premium research materials. We also offer custom synthesis services for unique research needs, further solidifying our commitment to advancing scientific understanding and therapeutic development in Parkinson's disease.