Parkinson's disease (PD) remains a significant neurodegenerative disorder, and understanding its underlying mechanisms is paramount for developing effective treatments. A key player in PD pathogenesis is the leucine-rich repeat kinase-2 (LRRK2) gene, mutations in which are a leading cause of familial PD and a significant risk factor for sporadic PD. Consequently, LRRK2 has emerged as a prime therapeutic target.

Inhibiting LRRK2 activity has shown promise in preclinical models of PD by alleviating neurotoxicity associated with specific LRRK2 mutations, such as the G2019S variant. This therapeutic strategy aims to normalize cellular processes that are disrupted by aberrant LRRK2 kinase activity, potentially slowing or halting disease progression. Researchers worldwide are actively seeking potent and selective LRRK2 inhibitors to explore these avenues.

One such critical compound for these investigations is N-(2-(2-(2-Methoxy-4-Morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)Methanesulfonamide, identified by CAS number 1191911-26-8. This molecule stands out due to its potent and selective inhibition of LRRK2, with reported IC50 values in the nanomolar range for both wild-type and mutant forms. Its cell-permeable nature further enhances its utility in cellular assays, allowing researchers to directly study its effects within neuronal environments. Early studies indicate its ability to attenuate LRRK2-induced injury in both rodent and human neurons, offering a crucial tool for researchers investigating neuroprotective strategies.

For those involved in drug discovery and neuroscientific research, obtaining high-quality N-(2-(2-(2-Methoxy-4-Morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)Methanesulfonamide is essential. As a trusted manufacturer and supplier based in China, we are committed to providing researchers with this vital pharmaceutical intermediate. Our commitment ensures high purity, consistent quality, and competitive pricing, making advanced research tools more accessible. We encourage scientists to buy this compound from us to support their studies in Parkinson's disease and related neurological conditions. If you are looking to purchase this LRRK2 inhibitor, we provide reliable sourcing and are a leading manufacturer in the field. Get a quote for your research needs and explore our custom synthesis services for your specific project requirements.

The ongoing research into LRRK2 inhibitors, including compounds like N-(2-(2-(2-Methoxy-4-Morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)Methanesulfonamide, represents a significant step forward in our quest to combat Parkinson's disease. As a dedicated supplier, we are proud to contribute to this critical scientific endeavor by offering essential, high-purity research chemicals to the global scientific community.