For researchers in pharmacology and drug development, understanding how the body processes and eliminates drugs is fundamental. Antipyrine, identified by its CAS number 60-80-0, plays a unique and important role in this field as a widely used marker for assessing hepatic drug-metabolizing enzyme activity. This article explores the specific applications of Antipyrine in drug metabolism studies and guides researchers on sourcing high-quality material for their experiments.

Antipyrine, also known as phenazone, is a synthetic pyrazolone derivative that has been in medical use for over a century. While it possesses analgesic and antipyretic properties, its value in contemporary research often lies in its well-characterized pharmacokinetic profile. The compound is primarily metabolized in the liver by the cytochrome P450 (CYP) enzyme system, particularly CYP1A2 and CYP3A4. Because its clearance rate is influenced by the activity of these enzymes, Antipyrine serves as an effective probe to evaluate an individual's or a population's drug-metabolizing capacity.

Researchers frequently buy Antipyrine for use in clinical studies to determine how various factors—such as genetic polymorphisms, disease states, or co-administered drugs—affect the activity of hepatic enzymes. For instance, administering a standard dose of Antipyrine and then measuring its concentration in plasma or urine over time allows scientists to calculate its metabolic clearance. A faster clearance rate suggests higher enzyme activity, while a slower rate indicates reduced activity. This data is invaluable for predicting potential drug-drug interactions or understanding variations in drug response among patients.

The accuracy of these studies heavily relies on the purity and consistency of the Antipyrine used. Therefore, it is crucial for researchers to source Antipyrine from reputable suppliers who can guarantee pharmaceutical grade or high-purity material. When looking to buy Antipyrine for research, key criteria include: high purity (typically >99%), a well-defined Certificate of Analysis (CoA) detailing assay methods and impurity profiles, and consistent batch-to-batch quality. Many suppliers offer Antipyrine in various quantities, suitable for both pilot studies and larger clinical trials.

For researchers operating with limited budgets, exploring suppliers from regions known for competitive chemical manufacturing, such as China, can be advantageous. Engaging with a reliable Antipyrine supplier in China requires due diligence. It is advisable to request quotes that clearly specify product details, quality assurance measures, and shipping logistics. Understanding the CAS number (60-80-0) when placing orders ensures that the correct compound is procured for specific research protocols.

In summary, Antipyrine (CAS: 60-80-0) is an indispensable tool for drug metabolism and pharmacokinetic research. Its utility as a probe for hepatic enzyme activity makes it a staple in studies aimed at understanding drug behavior in the body. By prioritizing high-quality sourcing and working with trusted manufacturers and suppliers, researchers can effectively leverage Antipyrine to advance their scientific investigations and drug development efforts.