For the research and development scientist, sourcing reliable chemical compounds is fundamental to successful experimentation and product innovation. Antipyrine, identified by CAS number 60-80-0, is a well-established pharmaceutical intermediate with a rich history and diverse applications. Understanding its properties, its role in research, and how to effectively source it from reputable manufacturers is key for R&D professionals.

Antipyrine, also known by its chemical name phenazone, is a synthetic pyrazolone derivative that has been utilized in medicine since the late 19th century. Its primary pharmacological actions are analgesic (pain relief) and antipyretic (fever reduction). It functions by inhibiting the synthesis of prostaglandins, which are key mediators of pain, fever, and inflammation. This makes Antipyrine a valuable active pharmaceutical ingredient (API) for various medicinal products. For R&D purposes, accessing this compound with high purity, often exceeding 99%, is critical to ensure accurate and reproducible results.

In the research arena, Antipyrine's significance extends beyond its direct therapeutic effects. It is widely employed as a metabolic probe to study the activity of hepatic drug-metabolizing enzymes, especially the cytochrome P450 (CYP) superfamily. By administering Antipyrine and measuring its clearance rate, researchers can gain insights into the metabolic capacity of the liver. This is particularly useful in pharmacokinetics studies, drug-drug interaction assessments, and in evaluating the impact of environmental factors or disease states on drug metabolism. Scientists often buy Antipyrine for these precise biochemical assays.

When sourcing Antipyrine for R&D, it is important to consider the supplier's reputation and the quality documentation provided. A reliable Antipyrine supplier will offer a detailed Certificate of Analysis (CoA) that confirms the compound's identity, purity, and relevant physical and chemical properties, such as appearance (typically a white crystalline powder), melting point, and specific assay methods used (e.g., HPLC). For researchers, understanding the CAS number (60-80-0) is essential for unambiguous identification when placing orders.

For international buyers, China has emerged as a significant hub for the production of pharmaceutical intermediates and fine chemicals. Many Chinese manufacturers offer Antipyrine at competitive prices, making it an accessible option for research institutions and companies with budget constraints. When seeking to buy Antipyrine from China, it is advisable to work with suppliers who have a track record of quality and reliable international shipping. Requesting a quote for Antipyrine should include inquiries about shipping conditions, regulatory compliance, and any necessary import documentation.

In conclusion, Antipyrine (CAS: 60-80-0) is a versatile compound with established roles in therapeutic formulations and critical functions in R&D as a metabolic probe. For researchers and developers, securing a consistent supply of high-purity Antipyrine from dependable sources is paramount. By prioritizing quality, understanding the specific research applications, and engaging with reputable manufacturers, scientists can ensure they have the necessary materials to drive their projects forward.