The pharmaceutical industry's success hinges on the precise synthesis of Active Pharmaceutical Ingredients (APIs), which in turn relies on a consistent supply of high-quality intermediates. Among these vital building blocks is Sacubitril (CAS 149709-62-6), a compound playing a significant role in modern cardiovascular drug development. For R&D scientists and procurement specialists, a deep understanding of its properties is essential for effective sourcing and utilization.

Sacubitril Intermediate: Chemical Profile and Significance

Sacubitril, identified by its CAS number 149709-62-6, is a pharmaceutical intermediate characterized by its high purity, typically specified at ≥99%. Its physical appearance is described as a colorless transparent oily liquid. The compound's molecular formula is C24H29NO5, with a molecular weight of 411.49. These chemical identifiers are critical for ensuring the correct compound is sourced and used in synthesis processes.

Key Chemical and Physical Properties

  • Appearance: Colorless transparent oily liquid.
  • Purity: ≥99% is the standard for pharmaceutical applications, ensuring minimal impurities that could affect the final API.
  • Molecular Formula: C24H29NO5.
  • Molecular Weight: 411.49 g/mol.
  • Density: Approximately 1.151±0.06 g/cm³.
  • Boiling Point: Around 656.9±55.0°C.

These properties are not merely descriptive; they are crucial for chemists when designing synthesis routes, optimizing reaction conditions, and ensuring the stability and efficacy of the intermediate during storage and handling. Understanding these parameters helps predict behavior in various chemical environments.

Applications in API Synthesis

The primary application of Sacubitril intermediate is in the synthesis of APIs used for treating cardiovascular conditions, most notably heart failure. As a precursor to drugs like Sacubitril/Valsartan (Entresto), it enables the production of medications that significantly improve patient prognosis. For pharmaceutical companies looking to manufacture these life-saving drugs, sourcing high-quality Sacubitril intermediate from a reliable manufacturer is a critical step. Whether you are looking to buy small quantities for early-stage research or bulk orders for large-scale API production, ensuring the purity and consistency of this intermediate is paramount.

Sourcing and Procurement Considerations

When procuring Sacubitril intermediate, prospective buyers should always request detailed product specifications and CoAs from their chosen supplier. Companies often seek out manufacturers in regions like China due to competitive pricing and established production capabilities. It is advisable to get multiple quotes and compare not only price but also delivery times, packaging, and the supplier's overall reputation and technical support. A responsive supplier who can provide accurate documentation and reliable delivery is invaluable.

In conclusion, Sacubitril intermediate (CAS 149709-62-6) is an indispensable component in the pharmaceutical industry, facilitating the creation of advanced cardiovascular therapies. A thorough understanding of its chemical properties and a commitment to sourcing from reputable suppliers are key to successful API development.