The realm of heterocyclic chemistry is rich with compounds that form the backbone of many modern innovations, particularly in pharmaceuticals and material science. Among these, benzo[b]thiophene derivatives have garnered significant attention for their versatile chemical properties and diverse applications. This article specifically examines 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene (CAS: 1034305-17-3), a compound of interest for researchers, and discusses essential considerations for sourcing it from global manufacturers and suppliers.

Understanding Benzo[b]thiophene Derivatives

Benzo[b]thiophene is a bicyclic aromatic compound consisting of a benzene ring fused with a thiophene ring. This core structure can be functionalized in numerous ways, leading to a wide array of derivatives with tailored properties. The specific compound, 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene, features a benzyl substituent at the 2-position of the benzo[b]thiophene ring. This substituent is further modified with bromine and fluorine atoms on the phenyl ring. These halogen substitutions are strategically important as they can influence lipophilicity, electronic distribution, and reactivity, often enhancing a molecule's biological activity or material performance.

Properties and Applications of 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene

This particular derivative is primarily recognized as a pharmaceutical intermediate. Its physical form is typically a white to off-white solid, with a predicted boiling point around 408.9 °C and a density of approximately 1.509 g/cm³. The presence of both bromine and fluorine atoms, along with the extended aromatic system, suggests potential for varied chemical interactions and synthetic utility. As a key intermediate, it plays a role in the synthesis of more complex molecules, including active pharmaceutical ingredients (APIs). For researchers and chemical procurement specialists looking to buy this compound, understanding its specific roles and properties is paramount.

Sourcing Strategies and Supplier Landscape

When seeking to acquire 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene, a global perspective on sourcing is beneficial. Numerous chemical manufacturers and suppliers worldwide offer this compound. China, in particular, has emerged as a significant hub for the production of fine chemicals and pharmaceutical intermediates, often providing competitive pricing and readily available stock. When you consider purchasing this intermediate, it's important to evaluate potential suppliers based on several criteria:

  • Purity Levels: Aim for suppliers who can guarantee high purity (e.g., ≥97%).
  • Reliability of Supply: Look for manufacturers with consistent production capabilities and a stable supply chain.
  • Technical Documentation: Ensure they provide comprehensive Certificates of Analysis (CoA) and Safety Data Sheets (SDS).
  • Customer Support and Pricing: Compare pricing for different quantities and assess the responsiveness of their sales and technical teams.

Directly inquiring with established manufacturers for quotes is often the most effective way to secure this vital chemical building block. Whether for R&D or larger-scale production, a well-chosen supplier is key to project success.