For research and development chemists, the selection of appropriate chemical intermediates is fundamental to successful innovation. Benzyl 3-oxo-1-piperidinecarboxylate (CAS: 61995-20-8) is one such compound, playing a significant role in organic synthesis, particularly within the pharmaceutical sector. This article aims to provide an in-depth look at its properties, common synthetic routes, and the advantages of sourcing it from reputable Chinese manufacturers.

Chemical Profile of Benzyl 3-oxo-1-piperidinecarboxylate

Benzyl 3-oxo-1-piperidinecarboxylate, also known as 1-Cbz-3-piperidinone, is an organic molecule with the chemical formula C₁₃H₁₅NO₃. It is typically described as a light yellow liquid with a purity of at least 97%. The compound features a piperidine ring substituted with a ketone group at the 3-position and a benzyloxycarbonyl (Cbz) protecting group attached to the nitrogen atom. This combination of functional groups imparts specific reactivity, making it an attractive building block for chemists designing complex organic structures.

Its key properties, such as a boiling point of approximately 384.1±42.0 °C at 760 mmHg and a density of around 1.2±0.1 g/cm³, are essential for process chemists to consider during scale-up and optimization. The presence of the Cbz group offers a stable amine protection strategy that can be readily removed under various conditions, while the ketone functionality allows for nucleophilic additions, reductions, and other carbonyl chemistry transformations.

Synthesis and Application in R&D

The synthesis of Benzyl 3-oxo-1-piperidinecarboxylate typically involves the reaction of 3-piperidone with benzyl chloroformate under basic conditions. This straightforward approach allows for the production of the intermediate in a controlled manner. In research and development settings, this compound is invaluable for:

  • Drug Discovery: Serving as a key intermediate in the synthesis of novel drug candidates, including potential treatments for neurological disorders and cancer.
  • Medicinal Chemistry: Facilitating the creation of diverse molecular libraries for structure-activity relationship (SAR) studies.
  • Organic Synthesis: Enabling the construction of complex heterocyclic systems and functionalized molecules for various research purposes.

Many chemists look to buy Benzyl 3-oxo-1-piperidinecarboxylate to integrate its unique structural elements into their target molecules, thereby accelerating the pace of discovery.

Strategic Sourcing from Chinese Manufacturers

For R&D departments, securing high-quality intermediates like Benzyl 3-oxo-1-piperidinecarboxylate at competitive prices is a strategic imperative. China has become a leading global supplier of fine chemicals and pharmaceutical intermediates. By choosing to purchase Benzyl 3-oxo-1-piperidinecarboxylate from China, research institutions and companies can benefit from:

  • Cost-Effectiveness: Accessing materials at favorable price points, which is critical for R&D budgets.
  • Scalability: Partnering with a manufacturer that can supply varying quantities, from gram-scale for initial research to kilogram-scale for pilot studies.
  • Quality Assurance: Relying on established suppliers who provide detailed Certificates of Analysis (CoA) confirming purity and specifications.

When looking to buy CAS 61995-20-8, it is advisable to work with a reputable supplier that has a proven track record in the fine chemical industry. This ensures product integrity and reliable delivery.

In conclusion, Benzyl 3-oxo-1-piperidinecarboxylate is a vital intermediate for modern organic synthesis and drug discovery. Its availability from quality-conscious Chinese manufacturers offers R&D chemists a strategic advantage in their pursuit of scientific advancement.