Bisphosphonates are a vital class of compounds in medicine and research, primarily known for their powerful effects on bone metabolism. Among these, Clodronate Disodium Salt (CAS 22560-50-5) holds a significant place due to its efficacy and diverse applications. For professionals in the chemical and pharmaceutical industries, understanding this compound, from its chemical structure to its sourcing, is essential for informed procurement and utilization.

What are Bisphosphonates?

Bisphosphonates are synthetic analogues of pyrophosphate, characterized by a P-C-P backbone. This structure grants them a high affinity for hydroxyapatite, the mineral component of bone. This affinity allows them to concentrate in bone tissue and inhibit the activity of osteoclasts, the cells responsible for bone resorption. This mechanism makes them highly effective in treating conditions involving excessive bone loss, such as osteoporosis, Paget's disease, and hypercalcemia associated with malignancy.

Clodronate Disodium Salt: A Closer Look

Clodronate Disodium Salt, with CAS number 22560-50-5, is a first-generation bisphosphonate. It is typically supplied as a white, crystalline powder and is characterized by its high water solubility and purity, often specified at 98% or higher. The presence of two chlorine atoms on the central carbon atom is a key structural feature influencing its pharmacological properties.

Beyond its well-established role in bone health, Clodronate Disodium Salt is also recognized for its effects on immune cells, particularly macrophages, where it can induce apoptosis. This has led to its use in research settings to study the role of macrophages in inflammation, immunity, and disease progression. As a pharmaceutical intermediate, it is also crucial in the synthesis of other active pharmaceutical ingredients (APIs).

Key Applications and Research Uses:

  • Treatment of Bone Diseases: While primarily a research compound now, its historical therapeutic applications underscore its potent bone resorption inhibitory effects.
  • Macrophage Depletion: In research, it's widely used to selectively eliminate macrophages, enabling studies on immune responses and disease pathogenesis.
  • Cancer Research: Its impact on bone and immune cells makes it relevant for understanding and treating skeletal metastases and related pain.
  • Immunomodulation Studies: Researchers utilize it to explore the complex interplay between immune cells and various disease states.

Sourcing Clodronate Disodium Salt from Reliable Suppliers

For professionals looking to buy Clodronate Disodium Salt, partnering with a reputable manufacturer and supplier, especially from China, is crucial. Factors to consider include:

  • Purity and Quality: Always verify the product's purity (≥98%) and review the Certificate of Analysis (COA).
  • Manufacturing Standards: Look for suppliers with established quality control systems.
  • Supply Chain Reliability: Ensure they can meet your required volumes consistently.
  • Competitive Pricing: Obtain quotes from multiple suppliers to ensure cost-effectiveness for your procurement budget.

Conclusion: A Vital Chemical for Research and Industry

Clodronate Disodium Salt (CAS 22560-50-5) is a foundational bisphosphonate with critical applications in bone research, immunology, and pharmaceutical development. Understanding its properties and securing a reliable supply from experienced manufacturers is paramount for scientific advancement. We are committed to being your trusted source for high-purity Clodronate Disodium Salt, supporting your research and industrial needs from China.