Boc-Lys-OMe.HCl (CAS 55757-60-3): A Cornerstone for Peptide Synthesis
The precision required in modern peptide synthesis necessitates the use of high-quality, well-defined building blocks. Boc-Lys-OMe.HCl, bearing the CAS number 55757-60-3, stands out as a cornerstone reagent in this critical area of chemistry. This protected amino acid derivative is fundamental for creating complex peptide chains, offering essential protection that ensures the integrity and efficiency of synthesis processes used across pharmaceutical, biotechnology, and academic research sectors.
Lysine, an amino acid characterized by its reactive side-chain amino group, presents unique challenges in peptide synthesis. To ensure that only the intended peptide bonds are formed, both the alpha-amino group and the alpha-carboxyl group of lysine must be temporarily protected. Boc-Lys-OMe.HCl provides this essential protection. The 'Boc' (tert-butoxycarbonyl) group acts as a stable shield for the alpha-amino functionality, while the methyl ester serves to protect the carboxyl group. This strategic arrangement allows for the controlled sequential addition of amino acids, preventing undesired side reactions and yielding the target peptide with high purity. When researchers decide to buy Boc-Lys-OMe.HCl, they are investing in a reliable method for precise peptide construction.
The compound's designation as a hydrochloride salt also contributes to its practical utility, often enhancing its solubility in common organic solvents utilized in synthesis reactions. This makes handling and processing the material more efficient, particularly when scaling up from laboratory benchtop to pilot or manufacturing scales. For professionals seeking to procure this compound, identifying a manufacturer that can guarantee consistent purity, typically above 98% or 99% as confirmed by analytical methods like Thin Layer Chromatography (TLC), is paramount.
The importance of Boc-Lys-OMe.HCl is underscored by its extensive use in drug discovery, where therapeutic peptides are increasingly developed for a variety of medical conditions. It also finds application in the synthesis of peptide-based biomaterials and in fundamental biochemical research aimed at understanding protein structure and function. Therefore, securing a dependable supply chain for this vital intermediate is a strategic priority for many research-driven organizations.
For those in the market to purchase Boc-Lys-OMe.HCl, engaging with established chemical manufacturers and suppliers is recommended. Obtaining detailed product specifications and Certificates of Analysis (CoA) is essential for quality assurance. Furthermore, requesting bulk quotations from trusted suppliers can lead to significant cost savings while maintaining the high standards necessary for successful scientific and pharmaceutical development. By prioritizing quality and reliability in sourcing this key building block, researchers can accelerate their progress and achieve greater success in their peptide synthesis endeavors.
Perspectives & Insights
Future Origin 2025
“Lysine, an amino acid characterized by its reactive side-chain amino group, presents unique challenges in peptide synthesis.”
Core Analyst 01
“To ensure that only the intended peptide bonds are formed, both the alpha-amino group and the alpha-carboxyl group of lysine must be temporarily protected.”
Silicon Seeker One
“The 'Boc' (tert-butoxycarbonyl) group acts as a stable shield for the alpha-amino functionality, while the methyl ester serves to protect the carboxyl group.”