For pharmaceutical manufacturers and research institutions, the cost-effective acquisition of high-purity chemical intermediates is a critical component of efficient operations. 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile (CAS: 189956-45-4), a key intermediate in the synthesis of the antiretroviral drug Rilpivirine, is a prime example. Understanding the factors influencing its price and availability for bulk purchase is essential for procurement planning.

Factors Influencing the Price of CAS 189956-45-4

The pricing of pharmaceutical intermediates like 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile is influenced by several market dynamics. When looking to buy this compound in bulk, consider the following:

  • Raw Material Costs: Fluctuations in the prices of upstream raw materials directly impact the manufacturing cost of the intermediate.
  • Production Scale and Efficiency: Manufacturers with optimized processes and large-scale production capabilities can generally offer more competitive prices per unit. Bulk purchases naturally benefit from economies of scale.
  • Purity and Quality Standards: Higher purity levels (e.g., ≥98.0% assay) and stringent quality control measures, including comprehensive COA documentation, often command a premium due to the increased production rigor required.
  • Supplier Location and Logistics: The geographical location of the manufacturer (e.g., China) and the associated shipping and logistics costs play a role in the final landed price.
  • Market Demand: The global demand for Rilpivirine and other potential applications of this intermediate directly influences its market price. High demand can lead to increased pricing.

Ensuring Availability for Bulk Orders

Securing a consistent and reliable supply of 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile for bulk purchase requires careful supplier selection. Manufacturers specializing in pharmaceutical intermediates, particularly those with established production lines and robust supply chain management, are best positioned to meet these demands. Key aspects to verify with a potential supplier include:

  • Production Capacity: Confirm their ability to fulfill large orders without compromising quality or lead times.
  • Inventory Management: Suppliers with proactive inventory management systems are more likely to have the product readily available.
  • Custom Synthesis Options: For specialized purity or formulation needs beyond standard specifications, inquire about custom synthesis services.
  • Contract Manufacturing Agreements: For long-term, high-volume requirements, establishing a contract manufacturing agreement can ensure dedicated production capacity and preferential pricing.

How to Obtain Quotes and Samples

To get the most accurate pricing and to assess product quality before committing to a bulk purchase, it is advisable to directly contact manufacturers and suppliers. Request detailed quotations that include unit price, minimum order quantity (MOQ), payment terms, and estimated lead times. Simultaneously, request samples for your internal R&D and quality assurance teams to evaluate. By diligently comparing offers and evaluating supplier capabilities, procurement professionals can secure the necessary quantities of 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile at favorable prices and with assured availability.