For procurement managers and R&D scientists in the pharmaceutical sector, securing high-quality intermediates is paramount. One such critical component is 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile, known by its CAS number 189956-45-4. This compound serves as a vital precursor in the synthesis of Rilpivirine, a cornerstone medication in the treatment of HIV. Understanding the sourcing landscape and key quality indicators for this specific intermediate is essential for ensuring the efficacy and safety of the final drug product.

Why is 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile Crucial?

Rilpivirine (CAS: 500287-72-9) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that plays a significant role in combination antiretroviral therapy. The synthesis of such complex pharmaceutical molecules relies on a series of precisely engineered intermediates. 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile, with its specific molecular structure (C11H8N4O, MW: 212.21), provides the necessary chemical scaffolding to build the Rilpivirine molecule effectively. Its purity and consistent quality directly impact the yield and quality of the final Active Pharmaceutical Ingredient (API).

Key Considerations for Buyers: Finding a Reliable Supplier

When looking to buy 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile, especially from manufacturers in China, several factors should guide your decision:

  • Purity Specifications: As indicated by available product details, a minimum purity of ≥98.0% is generally expected for pharmaceutical intermediates. Always request a Certificate of Analysis (COA) to verify lot-specific purity and conformity to specifications.
  • Supplier Reputation and Compliance: Partner with manufacturers who demonstrate robust quality management systems (e.g., ISO certification), good manufacturing practices (GMP), and a commitment to regulatory compliance. Companies with established R&D facilities and pilot production capabilities often offer more reliable products.
  • Production Capacity and Scalability: Ensure the supplier can meet your current and future volume requirements, from kilograms for early-stage development to tons for commercial production. A flexible manufacturing base is a significant advantage.
  • Technical Support and Documentation: A reputable supplier will provide comprehensive technical data, safety information (SDS), and potentially support with regulatory documentation, facilitating your internal evaluation and approval processes.
  • Price and Lead Time: While cost is a factor, it should not compromise quality. Compare pricing from multiple suppliers, but prioritize those offering a balance of competitive pricing, consistent quality, and reliable lead times. Inquire about bulk purchase discounts.

The Manufacturer's Role in the Supply Chain

As a direct manufacturer and supplier of pharmaceutical intermediates, we understand the critical nature of compounds like 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile. Our commitment is to provide a consistent, high-quality supply chain solution for companies engaged in Rilpivirine production. We focus on stringent quality control, efficient production processes, and responsive customer service. By choosing to purchase from a dedicated manufacturer, you can mitigate risks associated with supply chain disruptions and ensure access to a critical raw material at competitive prices. We welcome inquiries for quotations and samples, aiming to be your trusted partner in pharmaceutical intermediate procurement.

For R&D scientists and procurement professionals seeking a dependable source, understanding the detailed specifications and the supplier's capabilities is key to making an informed purchase decision for this vital pharmaceutical intermediate.