For pharmaceutical manufacturers focused on producing vital medications like Empagliflozin, securing a consistent and high-quality supply of key intermediates is a top priority. One such critical component is 2,3,4,6-Tetra-O-acetyl-D-gluconolactone (CAS 61259-48-1). Understanding the source, specifications, and procurement channels for this material can significantly streamline your API production process. As a dedicated manufacturer and supplier, we provide insights into why this intermediate is essential and how to procure it effectively.

The Significance of 2,3,4,6-Tetra-O-acetyl-D-gluconolactone in Empagliflozin Synthesis

Empagliflozin is a cornerstone in the treatment of type 2 diabetes, working by inhibiting the sodium-glucose cotransporter 2 (SGLT2). The synthesis of Empagliflozin involves multiple complex chemical steps, and 2,3,4,6-Tetra-O-acetyl-D-gluconolactone plays a crucial role as a foundational building block. Its structure, featuring a gluconolactone core protected by acetyl groups, allows for controlled stereochemistry and regioselectivity during the various reaction stages. Ensuring the purity and quality of this intermediate directly translates to the efficiency of the synthesis and the final API’s compliance with pharmaceutical standards.

Key Considerations When You Buy This Intermediate:

  • Purity Standards: For pharmaceutical applications, a purity level of 95.0% or higher is typically required. Higher purity intermediates minimize the risk of unwanted byproducts and simplify downstream purification, reducing overall manufacturing costs.
  • CAS Number: Confirming the CAS number 61259-48-1 is essential to ensure you are sourcing the correct chemical entity.
  • Supplier Reliability: Partnering with a reputable manufacturer, especially one with a strong presence in China, can offer significant advantages in terms of cost, scale, and consistency. Look for suppliers who provide detailed product specifications and Certificates of Analysis (CoA).
  • Packaging and Storage: Appropriate packaging and storage conditions (often cool and ventilated) are vital to maintain the integrity and shelf-life of the intermediate.

Where to Find a Quality Manufacturer

When you need to buy 2,3,4,6-Tetra-O-acetyl-D-gluconolactone for Empagliflozin production, seeking out experienced manufacturers is key. Companies specializing in pharmaceutical intermediates often have the necessary expertise in quality control, synthesis optimization, and regulatory compliance. We, as a leading supplier in China, are committed to delivering high-quality materials that meet the demanding requirements of the pharmaceutical industry. Our aim is to support your production needs with reliable supply and competitive pricing.

If your R&D or manufacturing operations require this essential intermediate, we encourage you to contact us for a quotation and further information on our product specifications and supply capabilities. Ensuring the quality of your starting materials is the first step towards successful drug manufacturing.