In the realm of fine chemicals and pharmaceutical intermediates, understanding the precise properties and applications of each compound is crucial for efficient research and manufacturing. 2,3,4,6-Tetra-O-acetyl-D-gluconolactone, identified by CAS Number 61259-48-1, is a prime example of a versatile intermediate with significant utility, particularly in pharmaceutical synthesis and carbohydrate chemistry. As a leading supplier, we aim to provide comprehensive insights into this valuable compound.

Chemical Identity and Properties

Chemical Name: 2,3,4,6-Tetra-O-acetyl-D-gluconolactone
CAS Number: 61259-48-1
Molecular Formula: C14H18O10
Molecular Weight: 346.287 g/mol
Appearance: Typically described as a light yellow liquid or crystal. This physical state can depend on purity and storage conditions.
Purity: Commonly available at a purity of ≥95.0%, which is suitable for most demanding synthetic applications.

The structure of 2,3,4,6-Tetra-O-acetyl-D-gluconolactone features a D-gluconolactone core with acetyl groups esterified to the hydroxyls at positions 2, 3, 4, and 6. These acetyl groups serve as protecting groups, rendering the hydroxyls less reactive and allowing for controlled chemical transformations. The lactone ring itself can also undergo various reactions, such as ring-opening, which is leveraged in many synthetic pathways.

Key Applications and Utility

The primary applications of this compound stem from its role as an intermediate in complex organic synthesis:

  • Pharmaceutical Synthesis: It is a critical precursor in the synthesis of important drugs, notably Empagliflozin and Dapagliflozin, both used in treating type 2 diabetes. Manufacturers relying on these synthesis routes will need a stable supply of this intermediate.
  • Glycosylation Processes: The compound is an excellent starting material for glycosylation reactions, essential for creating complex carbohydrates, glycoconjugates, and glycopeptides. These are vital in glycobiology research and the development of carbohydrate-based therapeutics.
  • Organic Synthesis Building Block: Its protected functionalities and reactive lactone ring make it a versatile building block for a wide array of organic molecules, providing researchers with a controllable way to introduce gluco-derived structures.

Procurement from a Reliable Manufacturer

For companies looking to buy 2,3,4,6-Tetra-O-acetyl-D-gluconolactone, especially in bulk quantities for pharmaceutical manufacturing, sourcing from a reputable supplier in China is a common and effective strategy. We offer this intermediate with guaranteed purity and consistent quality. Our expertise ensures that you receive a product that meets stringent specifications, supporting your critical synthesis needs. If you require this compound for your ongoing research or manufacturing, we encourage you to contact us for a quote and discuss your specific requirements. We are committed to being your trusted partner for high-quality chemical intermediates.