For chemists and procurement specialists engaged in sophisticated chemical synthesis, the quality and availability of building blocks like 4-Ethyl-5-fluoropyrimidine are paramount. This particular compound, with CAS number 137234-88-9, serves as a critical intermediate, especially in the pharmaceutical sector, notably in the synthesis of antifungal agents such as Voriconazole. When looking to purchase this chemical, understanding the key attributes and sourcing channels is vital for successful outcomes.

Understanding the Product: 4-Ethyl-5-fluoropyrimidine

4-Ethyl-5-fluoropyrimidine is a fluorinated pyrimidine derivative. Its chemical structure makes it a versatile synthon for a range of organic reactions. The purity of the compound is a significant factor, with typical specifications ranging from ≥97% to higher for specialized applications. The typical appearance is a colorless to light yellow liquid. Its utility extends across various research and development projects, from early-stage drug discovery to process optimization for large-scale manufacturing.

Where to Buy: Key Suppliers and Manufacturers

When searching for where to buy 4-Ethyl-5-fluoropyrimidine, it's important to consider reliable sources that can guarantee quality and consistency. Prominent suppliers and manufacturers often specialize in pharmaceutical intermediates and fine chemicals. These companies typically offer:

  • High Purity Grades: Ensuring the product meets the demanding purity requirements for pharmaceutical synthesis is non-negotiable. Always check for detailed Certificates of Analysis (CoA).
  • Various Quantities: From laboratory-scale grams to bulk manufacturing kilograms, reputable suppliers cater to different needs.
  • Competitive Pricing: Obtaining quotes from several sources is advisable to secure the best possible price, especially for larger orders.
  • Global Distribution: Many suppliers have established logistics networks to ship internationally, ensuring accessibility for researchers and manufacturers worldwide.

Factors to Consider When Purchasing:

Beyond the basic product information, several factors should guide your purchasing decision:

  • Supplier Reputation and Certification: Look for ISO-certified manufacturers or suppliers with a strong track record in the chemical industry. Customer reviews and testimonials can also provide valuable insights.
  • Technical Data and Support: Access to comprehensive technical data sheets (TDS), Material Safety Data Sheets (MSDS), and responsive technical support can be invaluable for process development.
  • Lead Times and Inventory: Understand the supplier's stock levels and typical delivery times. For critical projects, ensuring a consistent and timely supply is essential.
  • Regulatory Compliance: Verify that the supplier adheres to all relevant chemical regulations and can provide necessary documentation for import/export if applicable.

Leveraging 4-Ethyl-5-fluoropyrimidine in Synthesis

As a vital intermediate, 4-Ethyl-5-fluoropyrimidine is frequently employed in the synthesis of antifungal agents like Voriconazole. Its fluorinated pyrimidine structure is key to the bioactivity of the final drug. Researchers often use it as a foundational element to build more complex molecular structures, making it a sought-after commodity in synthetic chemistry laboratories.

In conclusion, to buy 4-Ethyl-5-fluoropyrimidine, focus on suppliers who prioritize purity, reliability, and customer service. By carefully evaluating potential partners, you can ensure access to this critical chemical intermediate, facilitating the successful progression of your synthetic chemistry endeavors.