For procurement managers in the pharmaceutical industry, sourcing high-quality intermediates like 4-Ethyl-5-fluoropyrimidine is paramount. This chemical building block plays a crucial role in the synthesis of vital medications, most notably the antifungal agent Voriconazole. Understanding the nuances of procurement, including purity standards, supplier reliability, and competitive pricing, can significantly impact your production efficiency and cost-effectiveness.

Understanding 4-Ethyl-5-fluoropyrimidine: The Basics

4-Ethyl-5-fluoropyrimidine (CAS: 137234-88-9) is a heterocyclic organic compound. Its structure, featuring an ethyl group and a fluorine atom on a pyrimidine ring, makes it a valuable synthon in organic chemistry. The compound is typically supplied with a purity of ≥97%, which is a critical factor for its use in pharmaceutical synthesis where even minor impurities can affect the final API's efficacy and safety profile. Its physical appearance is often described as a colorless to light yellow liquid.

Why is it Important in Pharmaceutical Manufacturing?

The primary significance of 4-Ethyl-5-fluoropyrimidine lies in its role as a key intermediate in the synthesis of Voriconazole. Voriconazole is a broad-spectrum triazole antifungal medication used to treat serious fungal infections. The efficient and reliable supply of 4-Ethyl-5-fluoropyrimidine directly impacts the manufacturing capacity and cost of Voriconazole. Therefore, securing a consistent supply from a reputable manufacturer is a strategic imperative for pharmaceutical companies.

Key Considerations for Buyers: Purity, Price, and Reliability

When looking to buy 4-Ethyl-5-fluoropyrimidine, procurement professionals should focus on several key aspects:

  • Purity Standards: Ensure the supplier provides a Certificate of Analysis (CoA) that clearly states the purity level, typically 97% or higher. Traceability and detailed analytical data are essential.
  • Supplier Reputation: Partner with established manufacturers and suppliers who have a proven track record in the fine chemical or pharmaceutical intermediate market. Look for suppliers with robust quality management systems.
  • Pricing and Bulk Options: Obtain quotes for your required quantities. Competitive pricing is crucial, especially for large-scale production. Inquire about bulk purchase discounts and long-term supply agreements.
  • Lead Times and Logistics: Understand the supplier's production capacity and typical lead times for delivery. Efficient logistics, especially for international shipments, are vital.
  • Technical Support: A good supplier will offer technical support to address any queries regarding the product's application, handling, or storage.

Finding Your Trusted Supplier in China

China is a major hub for chemical manufacturing, offering numerous suppliers of pharmaceutical intermediates. When selecting a supplier, consider those who specialize in heterocyclic compounds and have experience serving the pharmaceutical industry. By conducting thorough due diligence, you can identify a reliable manufacturer that meets your quality and volume requirements, ensuring the smooth progression of your drug development projects.

In conclusion, sourcing 4-Ethyl-5-fluoropyrimidine requires a strategic approach. By focusing on purity, supplier reliability, and competitive pricing, pharmaceutical buyers can secure a critical raw material that underpins the production of life-saving antifungal medications. For your procurement needs, consider established manufacturers and distributors who can guarantee quality and consistent supply.