For research and development scientists and procurement professionals in the pharmaceutical industry, sourcing high-quality chemical intermediates is a critical step in drug discovery and development. (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate, identified by CAS number 102123-74-0, is a vital building block, particularly recognized for its role in the synthesis of important APIs like Darunavir. This guide provides essential considerations when looking to buy this compound.

The first and foremost factor when procuring any pharmaceutical intermediate is purity. (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate typically comes as a White crystalline powder, and its assay value should ideally be ≥98.0%. Higher purity minimizes the risk of side reactions, ensures the integrity of subsequent synthesis steps, and ultimately contributes to the safety and efficacy of the final drug product. When you request a quote for CAS 102123-74-0, always ask for the Certificate of Analysis (CoA) detailing the purity and relevant impurity profiles.

Supplier reliability is another cornerstone of successful procurement. As a crucial intermediate, consistent availability is key to maintaining uninterrupted R&D timelines and manufacturing schedules. When searching for a supplier, consider their experience in handling pharmaceutical intermediates, their production capacity, and their track record for timely delivery. Partnering with a manufacturer that offers bulk supply and contract manufacturing can provide a stable, long-term solution. For those sourcing from China, selecting a manufacturer with a proven history of international trade and quality compliance is advisable.

Cost-effectiveness is, of course, a significant consideration. However, it should never come at the expense of quality. When comparing prices for (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate, evaluate the total value proposition. This includes not only the price per kilogram but also the consistency of quality, the reliability of supply, and the support services offered by the supplier. For instance, a supplier offering custom packaging or responsive technical support might justify a slightly higher initial price.

The specific application of this intermediate, primarily in Darunavir synthesis, means that its chiral purity is of utmost importance. Manufacturers should be able to confirm the stereochemistry of their product. For R&D scientists, understanding the typical reaction parameters and any known limitations or advantages of using this particular intermediate in their specific synthetic routes is also beneficial. Engaging with suppliers who can provide basic application guidance or technical data can further enhance the purchasing decision.

In summary, when it comes to buying (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate (CAS 102123-74-0), focus on high purity, reliable supplier partnerships, and a balanced approach to cost. Thorough due diligence will ensure you obtain a critical intermediate that supports the success of your pharmaceutical research and development efforts.