For professionals in the pharmaceutical industry, sourcing high-quality intermediates is paramount to successful drug development and manufacturing. One such critical compound is 2-Cyano-N,N-diethylacetamide, identified by its CAS number 26391-06-0. This intermediate plays a vital role, particularly in the synthesis of Entacapone, a key medication used in managing Parkinson's disease. Understanding the nuances of its procurement, from purity standards to reliable suppliers, is essential for R&D scientists and procurement managers.

Understanding 2-Cyano-N,N-diethylacetamide

2-Cyano-N,N-diethylacetamide is an organic compound characterized by its specific molecular formula C7H12N2O. It is valued for its role as a building block in complex organic synthesis. Its structure, featuring both a cyano group and a diethylacetamide moiety, allows for versatile chemical reactions, making it indispensable for creating specific molecular architectures. When considering purchasing this chemical, one must prioritize its purity and assay, as these directly impact the efficiency and outcome of subsequent synthesis steps. A minimum assay of 98.0% is often required for pharmaceutical applications.

Key Applications in Pharmaceutical Synthesis

The primary application that drives the demand for 2-Cyano-N,N-diethylacetamide is its use as an intermediate in the synthesis of Entacapone. Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, which enhances the efficacy of levodopa in treating Parkinson's disease by increasing dopamine levels in the brain. The successful synthesis of Entacapone relies heavily on the consistent quality and availability of its precursors. Beyond Entacapone, this versatile intermediate is also explored in the synthesis of other N-heterocyclic compounds, which are prevalent in various pharmacologically active molecules.

Sourcing Considerations: Purity, Price, and Suppliers

When looking to buy 2-Cyano-N,N-diethylacetamide, several factors come into play for B2B buyers. Firstly, purity is non-negotiable. Pharmaceutical applications demand intermediates with very low impurity profiles to avoid downstream contamination or reaction failures. Manufacturers typically provide an assay percentage, often determined by Gas Chromatography (GC), with 98.0% or higher being the standard for many uses.

Secondly, price is a significant consideration. Procurement managers constantly seek cost-effective solutions without compromising quality. Requesting quotes from multiple manufacturers and suppliers in China, known for its robust chemical manufacturing sector, can help secure competitive pricing for N,N-Diethylcyanoacetamide. Comparing different supplier offerings will provide a clearer picture of the market rate for this chemical intermediate.

Thirdly, the choice of supplier is crucial. Partnering with a reputable manufacturer or supplier ensures not only product quality but also reliability in supply chain management. Companies specializing in pharmaceutical intermediates, with ISO certifications and a track record of consistent delivery, are ideal. When you engage with a manufacturer, inquire about their production capacity, lead times, and regulatory documentation support, such as Certificates of Analysis (CoA).

Conclusion

For research scientists and procurement specialists in the pharmaceutical sector, securing a reliable supply of high-purity 2-Cyano-N,N-diethylacetamide (CAS: 26391-06-0) is a strategic imperative. By focusing on stringent purity standards, competitive pricing obtained through informed sourcing, and partnering with trustworthy manufacturers and suppliers, you can ensure the success of your synthesis projects. We are committed to providing top-tier pharmaceutical intermediates to meet your demanding requirements.