Calcium Folinate, also recognized as Leucovorin or Calcium Folinate, is a critical pharmaceutical compound with a dual role in modern medicine: treating specific types of anemia and acting as a vital adjunct in cancer chemotherapy. As a derivative of folic acid, it plays a pivotal part in cellular processes, making its availability and quality essential for therapeutic success. For procurement specialists and R&D scientists, understanding its applications and sourcing reliable suppliers is key.

One of the significant therapeutic uses of Calcium Folinate is in the management of megaloblastic anemia, particularly when oral administration is not feasible due to malabsorption issues, or in cases of nutritional deficiency, pregnancy, or infancy. This condition arises from a deficiency in folic acid, leading to the production of abnormally large red blood cells. Calcium Folinate effectively replenishes the body's folate levels, supporting normal red blood cell production. When sourcing this ingredient, looking for a pharmaceutical intermediate supplier that guarantees high purity is crucial.

In the realm of oncology, Calcium Folinate is perhaps most renowned for its role in 'Leucovorin rescue' protocols. When patients undergo high-dose Methotrexate therapy, a potent antifolate drug, Calcium Folinate is administered to rescue healthy cells from Methotrexate's cytotoxic effects. By providing an exogenous source of reduced folates, it bypasses the inhibited metabolic pathway, thereby reducing severe toxicity to bone marrow and mucous membranes. Pharmaceutical companies looking to buy Calcium Folinate (CAS 1492-18-8) for these critical applications require a dependable manufacturer in China known for consistent quality.

The efficacy of Calcium Folinate extends to combination therapies, notably with Fluorouracil (5-FU) in the treatment of advanced colorectal cancer. This combination has been shown to enhance the antitumour activity of 5-FU, leading to improved patient survival rates. The precise formulation and reliable supply of folinic acid calcium are paramount for the success of these complex treatment regimens.

For businesses seeking to procure this essential compound, exploring options to buy folinic acid in bulk or as a specific CAS 1492-18-8 chemical is a common requirement. We serve as a leading pharmaceutical raw material supplier in China, committed to providing premium quality Calcium Folinate. Our competitive Calcium Folinate price and established global distribution network make us an ideal partner for pharmaceutical manufacturers and research institutions worldwide.

In conclusion, Calcium Folinate is a cornerstone in managing certain anemias and a critical component in advanced cancer treatments. Whether for therapeutic applications or research, securing a reliable supply of high-purity folic acid calcium is essential. We invite you to inquire about our comprehensive range of pharmaceutical intermediates and experience the benefits of partnering with a trusted global supplier.