Calcium Folinate, also known by names like Leucovorin or Calcium Folinate, is a synthetic derivative of folic acid that holds significant importance as a pharmaceutical intermediate. Its applications are critical in managing challenging medical conditions, particularly in cancer chemotherapy and the treatment of folate-deficient anemias. For those in the pharmaceutical industry responsible for procurement and R&D, understanding the supply chain and quality aspects of this compound is essential.

In the field of oncology, Calcium Folinate is indispensable for its role as a rescue agent in Methotrexate therapy. Methotrexate, a powerful drug used to treat various cancers, works by inhibiting dihydrofolate reductase (DHFR), an enzyme crucial for DNA synthesis. This inhibition can lead to severe toxicity in healthy cells. Calcium Folinate, being a metabolically active form of folate, circumvents this inhibition by providing essential reduced folates, thereby protecting normal cells from Methotrexate's damaging effects. This 'Leucovorin rescue' is a standard practice in high-dose Methotrexate treatments for osteosarcoma, acute lymphoblastic leukemia, and certain lymphomas. The need for high-purity calcium folinate as a chemotherapy adjuvant is a constant driver in the market.

Furthermore, Calcium Folinate is a key component in combination therapies, particularly with 5-Fluorouracil (5-FU), to enhance treatment efficacy for advanced colorectal cancer. This synergistic effect underscores its value as a modulator in cancer treatment protocols. Consequently, the consistent availability of quality folinic acid calcium is vital for numerous treatment regimens.

Beyond its oncological applications, Calcium Folinate is therapeutically used to treat megaloblastic anemias caused by folate deficiency, especially when oral intake is insufficient or absorption is compromised. It directly addresses the metabolic deficit, facilitating the production of healthy red blood cells.

For businesses looking to procure this essential compound, identifying a reliable pharmaceutical intermediate supplier in China is a strategic move. We specialize in providing high-purity Calcium Folinate (CAS 1492-18-8), ensuring that our products meet the stringent quality requirements of the pharmaceutical industry. As a leading manufacturer in China, we are committed to consistent quality and dependable supply chains. Inquiries about Calcium Folinate price for bulk purchases are met with competitive offerings designed to support global healthcare needs.

When you need to buy folinic acid in bulk or source the specific CAS 1492-18-8 chemical, selecting an experienced and quality-focused partner is crucial. We operate as a proactive pharmaceutical raw material supplier, streamlining the procurement process for clients worldwide. Our aim is to ensure that you have access to reliable, high-grade Calcium Folinate, supporting critical medical treatments and research advancements.

In summary, Calcium Folinate's multifaceted role in modern medicine makes it a highly sought-after pharmaceutical intermediate. Its efficacy in cancer therapy support and anemia treatment highlights its importance. We invite you to partner with us for your Calcium Folinate needs, ensuring quality, reliability, and competitive sourcing from China.